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- Title
Carbazole Derivatives as STAT Inhibitors: An Overview.
- Authors
Caruso, Anna; Barbarossa, Alexia; Carocci, Alessia; Salzano, Giovanni; Sinicropi, Maria Stefania; Saturnino, Carmela
- Abstract
The carbazole class is made up of heterocyclically structured compounds first isolated from coal tar. Their structural motif is preponderant in different synthetic materials and naturally occurring alkaloids extracted from the taxonomically related higher plants of the genus Murraya, Glycosmis, and Clausena from the Rutaceae family. Concerning the biological activity of these compounds, many research groups have assessed their antiproliferative action of carbazoles on different types of tumoral cells, such as breast, cervical, ovarian, hepatic, oral cavity, and small-cell lung cancer, and underlined their potential effects against psoriasis. One of the principal mechanisms likely involved in these effects is the ability of carbazoles to target the JAK/STATs pathway, considered essential for cell differentiation, proliferation, development, apoptosis, and inflammation. In this review, we report the studies carried out, over the years, useful to synthesize compounds with carbazole moiety designed to target these kinds of kinases.
- Subjects
CARBAZOLE derivatives; COAL tar; CARBAZOLE; CELL differentiation; STAT proteins; LUNG cancer
- Publication
Applied Sciences (2076-3417), 2021, Vol 11, Issue 13, p6192
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app11136192