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- Title
Huntington disease alters the actionable information in plasma extracellular vesicles.
- Authors
Neueder, Andreas; Nitzschner, Philipp; Wagner, Ronja; Hummel, Julia; Hoschek, Franziska; Wagner, Maximilian; Abdelmoez, Alshaimaa; von Einem, Björn; Landwehrmeyer, G. Bernhard; Tabrizi, Sarah J.; Orth, Michael
- Abstract
This article explores the potential use of extracellular vesicles (EVs) as biomarkers for Huntington disease (HD). The researchers conducted a study using advanced bioinformatics and machine learning to analyze EVs from individuals with HD and healthy individuals. They discovered that EVs from HD individuals contained specific actionable information, indicating that EVs could be utilized as biomarkers in clinical trials. The study also investigated the composition and size distribution of EVs and generated proteomics and RNAseq datasets to gain a deeper understanding of the molecular changes associated with HD. Another study discussed in the article aimed to determine if the RNA content of EVs could serve as a biomarker for HD. The researchers found that the RNA content of EVs accurately distinguished between different stages of HD. They also observed that EVs can transfer information between cells, and the genetic origin of the EVs influenced the response of recipient cells. The study suggests that EVs could be a valuable source of biomarkers for HD and may have potential applications in clinical trials.
- Subjects
EXTRACELLULAR vesicles; HUNTINGTON disease; SPINOCEREBELLAR ataxia; HUMAN biology; GENE expression; LIFE sciences
- Publication
Clinical & Translational Medicine, 2024, Vol 14, Issue 1, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1525