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- Title
Multiomics‐based study of amniotic fluid small extracellular vesicles identified Moesin as a biomarker for antenatal hydronephrosis.
- Authors
Li, Jingzhi; Fu, Ying; Liu, Qiaoshu; Shen, Kuifang; Yao, Ruojin; Fu, Yimei; Lu, Yang; Xie, Mingkun; Jian, Wenyan; Guo, Ming; Dai, Lei; Zhang, Weishe
- Abstract
CON-sup, normal fetal amniotic fluid sEVs; ANH-sup, ANH amniotic fluid sEVs; CON-cell, normal fetal amniotic fluid cells; ANH-cell, ANH amniotic fluid cells. gl To further explore the special expression pattern in sEVs of ANH, we compared the proteins and mRNAs in sEVs between ANH and normal samples, respectively. Dear Editor, Antenatal hydronephrosis (ANH) is the most common congenital anomaly of the urinary tract. In this study, we extracted small extracellular vesicles riched samples (sEVs) from supernatant amniotic fluid (AF), identified and verified the high expressed Moesin as an effective biomarker for ANH diagnosis. We identified 116 differential expression proteins (Figure 3A, B; Tables S3) and 836 differential expression mRNAs (Figure 3E, F, TableS4) between ANH amniotic fluid sEVs (ANH-sup) and normal fetal amniotic fluid sEVs (CON-sup).
- Subjects
AMNIOTIC liquid; HYDRONEPHROSIS; EXTRACELLULAR vesicles; EXTRACELLULAR fluid; BIOMARKERS; AMNIOCENTESIS; GENE expression; FETAL surgery
- Publication
Clinical & Translational Medicine, 2023, Vol 13, Issue 8, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1360