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- Title
Predicting the retinal content in omega‐3 fatty acids for age‐related macular‐degeneration.
- Authors
Acar, Niyazi; Merle, Bénédicte M. J.; Ajana, Soufiane; He, Zhiguo; Grégoire, Stéphane; Hejblum, Boris P.; Martine, Lucy; Buaud, Benjamin; Bron, Alain M.; Creuzot‐Garcher, Catherine P.; Korobelnik, Jean‐François; Berdeaux, Olivier; Jacqmin‐Gadda, Hélène; Bretillon, Lionel; Delcourt, Cécile; Bron, Alain; Cabaret, Stéphanie; Gain, Philippe; Cougnard‐Grégoire, Audrey; Creuzot‐Garcher, Catherine
- Abstract
Adjusted differences black squares and 95% confidence intervals (CIs) (horizontal lines) of observed and predicted retinal -3 PUFAs contents for age-related macular degeneration in donor eyes and humans patients. Interestingly, cholesteryl esters species with -3 PUFAs contributed positively to the estimation of retinal -3 PUFAs content whereas those with -6 PUFAs lowered the prediction index, which is consistent with the well-established competitive metabolism of -3 and -6 PUFAs. Current treatments for age-related macular degeneration (AMD)-the leading cause of blindness in industrialized countries-are restricted to a single form of the disease and cannot always avoid severe visual loss.1 Among emerging preventive strategies, -3 polyunsaturated fatty acids (PUFAs) are enjoying interest as they promote normal retinal structure and function, reduce incidence, and slow progression of AMD, consistently with their abundance in retinal neurons.
- Subjects
OMEGA-3 fatty acids; MONOUNSATURATED fatty acids; BLOOD lipids; HDL cholesterol; LDL cholesterol; FISH oils; ZEAXANTHIN; LIPID metabolism
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 7, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.404