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- Title
Intentional weight loss in overweight and obese individuals and cognitive function: a systematic review and meta-analysis.
- Authors
Siervo, M.; Arnold, R.; Wells, J. C. K.; Tagliabue, A.; Colantuoni, A.; Albanese, E.; Brayne, C.; Stephan, B. C. M.
- Abstract
Summary High adiposity in middle age is associated with higher dementia risk. The association between weight loss and cognitive function in older adults is still controversial. A meta-analysis was undertaken to estimate the effectiveness of intentional weight loss on cognitive function in overweight and obese adults. A structured strategy was used to search randomized and non-randomized studies reporting the effect of intentional and significant weight loss on cognitive function in overweight and obese subjects. Information on study design, age, nutritional status, weight-loss strategy, weight lost and cognitive testing was extracted. A random-effect meta-analysis was conducted to obtain summary effect estimates for memory and attention-executive domains. Twelve studies met inclusion criteria. Seven were randomized trials and the remaining five included a control group. A low-order significant effect was found for an improvement in cognitive performance with weight loss in memory (effect size 0.13, 95% CI 0.00-0.26, P = 0.04) and attention/executive functioning (effect size 0.14, 95% CI 0.01-0.27, P < 0.001). Studies were heterogeneous in study design, sample selection, weight-loss intervention and assessment of cognitive function. Weight loss appears to be associated with low-order improvements in executive/attention functioning and memory in obese but not in overweight individuals.
- Subjects
OVERWEIGHT persons; WEIGHT loss; COGNITIVE ability; DEMENTIA; OBESITY; BODY mass index; SYSTEMATIC reviews; META-analysis
- Publication
Obesity Reviews, 2011, Vol 12, Issue 11, p968
- ISSN
1467-7881
- Publication type
Article
- DOI
10.1111/j.1467-789X.2011.00903.x