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- Title
Hairy cell leukemia cell lines expressing annexin A1 and displaying B-cell receptor signals characteristic of primary tumor cells lack the signature BRAF mutation to reveal unrepresentative origins.
- Authors
Weston-Bell, N J; Hendriks, D; Sugiyarto, G; Bos, N A; Kluin-Nelemans, H C; Forconi, F; Sahota, S S
- Abstract
The article discusses the study of absence of BRAF mutation in hairy cell leukemia (HCL) cell lines with expressions of annexin A1 gene and B-cell receptor signals indicating its unrepresentative origins. The study comprised of evaluation of six HCL cell lines and their comparison with primary tumors. Western blot analysis confirmed four cell lines as positive for expression of annexin A1 gene.
- Subjects
GENETIC mutation; HAIRY cell leukemia; CELL lines; WESTERN immunoblotting; B cells
- Publication
Leukemia (08876924), 2013, Vol 27, Issue 1, p241
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2012.163