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- Title
Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress.
- Authors
Khan, Naghma; Sharma, Sonia; Sultana, Sarwat
- Abstract
Potassium bromate (KBrO[sub 3]) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO[sub 3]-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO[sub 3] (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, γ-glutamyl transpeptidase, hydrogen peroxide and xanthine oxidase with reduction in the activities of renal antioxidant enzymes and renal glutathione content. A marked increase in blood urea nitrogen and serum creatinine has also been observed. KBrO[sub 3] treatment also enhances ornithine decarboxylase (ODC) activity and [[sup 3]H] thymidine incorporation into renal DNA. Prophylaxis of rats orally with Nigella sativa extract (50 mg/kg body weight and 100 mg/kg body weight) resulted in a significant decrease in renal micro-somal lipid peroxidation (P < 0.001), γ-glutamyl trans-peptidase (P < 0.001), H[sub 2]O[sub 2] (P < 0.001) and xanthine oxidase (P < 0.05). There was significant recovery of renal glutathione content (P < 0.01) and antioxidant enzymes (P < 0.001). There was also reversal in the enhancement of blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Data suggest that Nigella sativa is a potent chemopreventive agent and may suppress KBrO[sub 3]-mediated renal oxidative stress, toxicity and tumour promotion response in rats.
- Subjects
BLACK cumin; CHEMOPREVENTION; POTASSIUM compounds; CARCINOGENESIS; THERAPEUTICS
- Publication
Human & Experimental Toxicology, 2003, Vol 22, Issue 4, p193
- ISSN
0960-3271
- Publication type
Article
- DOI
10.1191/0960327103ht349oa