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- Title
Clinical dermatology • Concise report Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene.
- Authors
Byrne, J. S.; Razak, A. R. Abdul; Patchett, S.; Murphy, G. M.
- Abstract
The use of warfarin is rarely complicated by skin necrosis. We describe a 50-year-old woman who presented with a left leg deep venous thrombosis and subsequent pulmonary embolism. She was initially anticoagulated with low-molecular weight heparin and subsequently warfarin. Within 4 days abdominal skin necrosis developed. Investigations revealed the presence of protein S deficiency and in addition, a mutation in the methylenetetrahydrofolate reductase gene ( MTHFR). We present, to our best knowledge, the first case of warfarin skin necrosis associated with a methylenetetrahydrofolate reductase mutation.
- Subjects
WARFARIN; SKIN diseases; PROTEIN S deficiency; THROMBOSIS
- Publication
Clinical & Experimental Dermatology, 2004, Vol 29, Issue 1, p35
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.2004.01443.x