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- Title
Effects of vitamin D supplementation on FGF23: a randomized-controlled trial.
- Authors
Trummer, Christian; Schwetz, Verena; Pandis, Marlene; Grübler, Martin R.; Verheyen, Nicolas; Gaksch, Martin; Zittermann, Armin; März, Winfried; Aberer, Felix; Steinkellner, Julia; Friedl, Claudia; Brandenburg, Vincent; Voelkl, Jakob; Alesutan, Ioana; Obermayer-Pietsch, Barbara; Pieber, Thomas R.; Tomaschitz, Andreas; Pilz, Stefan
- Abstract
Purpose: Fibroblast growth factor-23 (FGF23) is critical for phosphate homeostasis. Considering the high prevalence of vitamin D deficiency and the association of FGF23 with adverse outcomes, we investigated effects of vitamin D3 supplementation on FGF23 concentrations. Methods: This is a post-hoc analysis of the Styrian Vitamin D Hypertension trial, a single-center, double-blind, randomized, placebo-controlled trial, conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two hundred subjects with 25(OH)D concentrations < 30 ng/mL and arterial hypertension were randomized to receive either 2800 IU of vitamin D3 daily or placebo over 8 weeks. Primary outcome was the between-group difference in FGF23 levels at study end while adjusting for baseline values. Results: Overall, 181 participants (mean ± standard deviation age, 60.1 ± 11.3; 48% women) with available c-term FGF23 concentrations were considered for the present analysis. Mean treatment duration was 54 ± 10 days in the vitamin D3 group and 54 ± 9 days in the placebo group. At baseline, FGF23 was significantly correlated with serum phosphate (r = 0.135; p = 0.002). Vitamin D3 supplementation had no significant effect on FGF23 in the entire cohort (mean treatment effect 0.374 pmol/L; 95% confidence interval − 0.024 to 0.772 pmol/L; p = 0.065), but increased FGF23 concentrations in subgroups with baseline 25(OH)D concentrations below 20 ng/mL (n = 70; mean treatment effect 0.973 pmol/L; 95% confidence interval − 0.032 to 1.979 pmol/L; p = 0.019) and 16 ng/mL (n = 40; mean treatment effect 0.593 pmol/L; 95% confidence interval 0.076 to 1.109; p = 0.022). Conclusions: Vitamin D3 supplementation had no significant effect on FGF23 in the entire study cohort. We did, however, observe an increase of FGF23 concentrations in subgroups with low baseline 25(OH)D.
- Subjects
AUSTRIA; THERAPEUTIC use of vitamin D; PHOSPHATE metabolism; ACADEMIC medical centers; CONFIDENCE intervals; DIETARY supplements; GROWTH factors; HOMEOSTASIS; PULMONARY hypertension; STATISTICAL sampling; STATISTICS; VITAMIN D deficiency; DATA analysis; RANDOMIZED controlled trials; DISEASE prevalence; TREATMENT duration; DESCRIPTIVE statistics
- Publication
European Journal of Nutrition, 2019, Vol 58, Issue 2, p697
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-018-1672-7