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- Title
Case Report: A Variety of Immune-Related Adverse Events Triggered by Immune Checkpoint Inhibitors in a Subject With Malignant Melanoma: Destructive Thyroiditis, Aseptic Meningitis and Isolated ACTH Deficiency.
- Authors
Katakura, Yukino; Kimura, Tomohiko; Kusano, Takashi; Tatsumi, Fuminori; Iwamoto, Yuichiro; Sanada, Junpei; Fushimi, Yoshiro; Shimoda, Masashi; Kohara, Kenji; Nakanishi, Shuhei; Kaku, Kohei; Mune, Tomoatsu; Kaneto, Hideaki
- Abstract
Recently, immune checkpoint inhibitors have been drawing much attention as cancer immunotherapy, but it has been shown that various immune-related adverse events (irAEs) are induced by immune checkpoint inhibitors in various organs, which has become one of the serious issues at present. A 58-year-old Japanese male with malignant melanoma was treated with nivolumab and/or ipilimumab. During the period of treatment, he suffered from various irAEs. Firstly, about 1 month after starting nivolumab monotherapy, destructive thyroiditis was induced, and so we started replacement therapy with levothyroxine. Secondly, about 1 month after starting nivolumab and ipilimumab combination therapy, aseptic meningitis was induced. We stopped both drugs and started steroid therapy with prednisolone. Finally, about 9 months after restarting nivolumab, isolated adrenocorticotropic hormone (ACTH) deficiency was induced, and so we started replacement therapy with hydrocortisone. Taken together, we should bear in mind the possibility of a variety of irAEs when we use immune checkpoint inhibitors.
- Subjects
DRUG side effects; IMMUNE checkpoint inhibitors; IPILIMUMAB; LEVOTHYROXINE; MELANOMA; STEROID drugs; ADRENOCORTICOTROPIC hormone
- Publication
Frontiers in Endocrinology, 2021, Vol 12, p1
- ISSN
1664-2392
- Publication type
Case Study
- DOI
10.3389/fendo.2021.722586