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- Title
Role of Non-Coding RNAs in the Etiology of Bladder Cancer.
- Authors
Gulìa, Caterina; Baldassarra, Stefano; Signore, Fabrizio; Rigon, Giuliano; Pizzuti, Valerio; Gaffi, Marco; Briganti, Vito; Porrello, Alessandro; Piergentili, Roberto
- Abstract
According to data of the International Agency for Research on Cancer and theWorld Health Organization (Cancer Incidence in Five Continents, GLOBOCAN, and theWorld Health Organization Mortality), bladder is among the top ten body locations of cancer globally, with the highest incidence rates reported in Southern andWestern Europe, North America, Northern Africa andWestern Asia. Males (M) are more vulnerable to this disease than females (F), despite ample frequency variations in different countries, with a M:F ratio of 4.1:1 for incidence and 3.6:1 for mortality, worldwide. For a long time, bladder cancer was genetically classified through mutations of two genes, fibroblast growth factor receptor 3 (FGFR3, for low-grade, non-invasive papillary tumors) and tumor protein P53 (TP53, for high-grade, muscle-invasive tumors). However, more recently scientists have shown that this disease is far more complex, since genes directly involved are more than 150; so far, it has been described that altered gene expression (up- or down-regulation) may be present for up to 500 coding sequences in low-grade and up to 2300 in high-grade tumors. Non-coding RNAs are essential to explain, at least partially, this ample dysregulation. In this review, we summarize the present knowledge about long and short non-coding RNAs that have been linked to bladder cancer etiology.
- Subjects
BLADDER cancer diagnosis; NON-coding RNA; FIBROBLAST growth factors; MICRORNA; EPIGENETICS
- Publication
Genes, 2017, Vol 8, Issue 11, p339
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes8110339