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- Title
Comparison of clinical features between primary and drug-induced sleep-related eating disorder.
- Authors
Yoko Komada; Yoshikazu Takaesu; Kentaro Matsui; Masaki Nakamura; Shingo Nishida; Meri Kanno; Akira Usui; Yuichi Inoue
- Abstract
Purpose: The aim of this study was to ascertain the clinical characteristics of drug-induced sleep-related eating disorder (SRED). Patients and methods: We retrospectively reviewed the medical records of 30 patients with primary SRED (without any comorbid sleep disorders and who were not taking any possible causative medications), and ten patients with drug-induced SRED (occurrence of SRED episodes after starting nightly medication of sedative drugs, which completely resolved after dose reduction or discontinuation of the sedatives). Results: All patients with drug-induced SRED took multiple types of sedatives, such as benzodiazepines or benzodiazepine receptor agonists. Clinical features of drug-induced SRED compared with primary SRED were as follows: higher mean age of onset (40 years old in drug-induced SRED vs 26 years old in primary SRED), significantly higher rate of patients who had total amnesia during most of their SRED episodes (75.0% vs 31.8%), significantly lower rate of comorbidity of night eating syndrome (0% vs 63.3%), and significantly lower rate of history of sleepwalking (10.0% vs 46.7%). Increased doses of benzodiazepine receptor agonists may be responsible for drug-induced SRED. Conclusion: The clinical features of drug-induced SRED were different from those of primary SRED, possibly reflecting differences in the underlying mechanisms between these two categories of SREDs.
- Subjects
EATING disorders; NIGHT eating syndrome; BENZODIAZEPINES; BENZODIAZEPINE receptors; COMORBIDITY
- Publication
Neuropsychiatric Disease & Treatment, 2016, Vol 12, p1275
- ISSN
1176-6328
- Publication type
Article
- DOI
10.2147/NDT.S107462