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- Title
Anti-inflammatory effects of apo-9′-fucoxanthinone from the brown alga, Sargassum muticum.
- Authors
Eun-Jin Yang; Young Min Ham; Wook Jae Lee; Nam Ho Lee; Chang-Gu Hyun
- Abstract
Background: The marine environment is a unique source of bioactive natural products, of which Sargassum muticum (Yendo) Fensholt is an important brown algae distributed in Jeju Island, Korea. S. muticum is a traditional Korean food stuff and has pharmacological functions including anti-inflammatory effects. However, the active ingredients from S. muticum have not been characterized. Methods: Bioguided fractionation of the ethanolic extract of S. muticum, collected from Jeju island, led to the isolation of a norisoprenoid. Its structure was determined by analysis of the spectroscopic data. In vitro anti-inflammatory activity and mechanisms of action of this compound were examined using lipopolysaccharide (LPS)-stimulated RAW 264.7 cells through ELISA assays and Western blot analysis. Results: Apo-9′-fucoxanthinone, belonging to the norisoprenoid family were identified. Apo-9′-fucoxanthinone effectively suppressed LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production. This compound also exerted their anti-inflammatory actions by down-regulating of NF-κB activation via suppression of IκB-α in macrophages. Conclusions: This is the first report describing effective anti-inflammatory activity for apo-9′-fucoxanthinone′-fucoxanthnone isolated from S. muticum. Apo-9′-fucoxanthinone may be a good candidate for delaying the progression of human inflammatory diseases and warrants further studies.
- Subjects
KOREA; CLASSIFICATION of algae; ANTI-inflammatory agents; CELL culture; ENZYME-linked immunosorbent assay; RESEARCH funding; T-test (Statistics); WESTERN immunoblotting; IN vitro studies
- Publication
DARU: Journal of Pharmaceutical Sciences, 2013, Vol 21, p62
- ISSN
1560-8115
- Publication type
Article
- DOI
10.1186/2008-2231-21-62