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- Title
Is Human Immunodeficiency Virus Infection a Risk Factor for Strongyloides stercoralis Hyperinfection and Dissemination.
- Authors
Siegel, Marc O.; Simon, Gary L.
- Abstract
The article discusses the relationship between human immunodeficiency virus (HIV) infection and Strongyloides stercoralis, a parasitic worm. While HIV infection does not protect against acquiring S. stercoralis, it does not appear to increase the risk of hyperinfection and dissemination of the parasite. The immune response in HIV-infected individuals is characterized by a decline in type 1 T helper (Th1) cells, which are responsible for cellular immunity, but relatively preserved activity of type 2 T helper (Th2) cells, which mediate humoral immunity. The Th2 response may play a role in preventing dissemination of S. stercoralis in HIV-infected individuals. Further research is needed to understand the immune interaction between HIV and S. stercoralis and its implications for vaccine development.
- Subjects
HIV infections; HIV; HUMORAL immunity; CELLULAR immunity; HELMINTHS
- Publication
PLoS Neglected Tropical Diseases, 2012, Vol 6, Issue 7, p1
- ISSN
1935-2727
- Publication type
Article
- DOI
10.1371/journal.pntd.0001581