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- Title
A novel method for the one-pot conversion of carboxylic acids to N,N-dimethylamides.
- Authors
Kaboudin, Babak; Haghighat, Hamideh
- Abstract
A simple, efficient, and new method has been developed for the preparation of N,N-dimethylamides from carboxylic acids. As described below, treatment of a variety of aromatic carboxylic acids with N,N-dimethylsulfamoyl imidazole or N,N-dimethylsulfamoyl chloride in the presence of a mixture of methanesulfonic acid/phosphorus pentoxide (2:1, v/w) proceeded effectively to afford the corresponding N,N-dimethylamides in moderate to good yields. This method is easy, rapid, and good yielding for the synthesis of N,N-dimethylamides from carboxylic acids.
- Subjects
AMIDES; SULFONIC acids; PHOSPHORIC anhydride; CARBOXYLIC acids; IMIDAZOLES; CHLORIDES; MIXTURES
- Publication
Journal of the Iranian Chemical Society, 2012, Vol 9, Issue 6, p951
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-012-0112-5