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- Title
Anti-nociceptive and anti-inflammatory effects of Withania somnifera root in fructose fed male rats.
- Authors
Shahraki, Mohammad Reza; Noshahr, Zahra Samadi; Ahmadvand, Hassan; Nakhaie, Alireza
- Abstract
Background: Insulin resistance is a metabolic disorder which affects the diabetes mellitus pathophysiology and alters the cell excitability. This study has been designed to evaluate the anti-nociceptive and anti-inflammatory effects of chronic administration of Withania somnifera root (WSR) in fructose drinking water rats. Methods: An experiment was carried out on 48 Wistar-Albino male rats, weighting 200±30 g, which were divided into six groups (n = 8): control group (C), control morphine (CM), W. somnifera group (WS) which received WSR (62.5 mg/g diet), W. somnifera naloxone group (WSN) which received WSR and naloxone, fructose (F) group which received fructose drinking water and FWS group which received fructose-enriched drinking water and WSR during the trial period. A biphasic pain response was induced after intraplantar injection of formalin (50 μL, 1%). Pain behavior was measured using Dubuisson methods. The obtained data were analyzed by SPSS software V. 18, using ANOVA and Tukey test. Results were expressed as mean±SD. Statistical differences were considered significant at p<0.05. Results: The results showed that the insulin resistance index, blood sugar, insulin, IL-6, TNF-α, and acute and chronic pain score in the F group were significantly increased in comparison with the control group, but these parameters in the FWS group were significantly decreased compared with the F group (p<0.001). Conclusions: Our findings indicated that chronic oral administration of WSR has analgesic and anti-inflammatory effects in fructose drinking water rats and causes improved insulin resistance index.
- Subjects
THERAPEUTIC use of plant extracts; ANALGESICS; ANALYSIS of variance; ANIMAL experimentation; ANTI-inflammatory agents; BLOOD sugar; CYTOKINES; FRUCTOSE; INSULIN; INSULIN resistance; NALOXONE; PAIN; PROBABILITY theory; RATS; STATISTICS; TUMOR necrosis factors; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; PHARMACODYNAMICS
- Publication
Journal of Basic & Clinical Physiology & Pharmacology, 2016, Vol 27, Issue 4, p387
- ISSN
0792-6855
- Publication type
Article
- DOI
10.1515/jbcpp-2015-0053