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- Title
T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects.
- Authors
Fang, Mingyan; Su, Zheng; Abolhassani, Hassan; Zhang, Wei; Jiang, Chongyi; Cheng, Bochen; Luo, Lihua; Wu, Jinghua; Wang, Shiyu; Lin, Liya; Wang, Xie; Wang, Longlong; Aghamohammadi, Asghar; Li, Tao; Zhang, Xiuqing; Hammarström, Lennart; Liu, Xiao
- Abstract
Both DNA damage response and methylation play a crucial role in antigen receptor recombination by creating a diverse repertoire in developing lymphocytes, but how their defects relate to T cell repertoire and phenotypic heterogeneity of immunodeficiency remains obscure. We studied the TCR repertoire in patients with the mutation in different genes (ATM, DNMT3B, ZBTB24, RAG1, DCLRE1C, and JAK3) and uncovered distinct characteristics of repertoire diversity. We propose that early aberrancies in thymus T cell development predispose to the heterogeneous phenotypes of the immunodeficiency spectrum. Shorter CDR3 lengths in ATM-deficient patients, resulting from a decreased number of nucleotide insertions during VDJ recombination in the pre-selected TCR repertoire, as well as the increment of CDR3 tyrosine residues, lead to the enrichment of pathology-associated TCRs, which may contribute to the phenotypes of ATM deficiency. Furthermore, patients with DNMT3B and ZBTB24 mutations who exhibit discrepant phenotypes present longer CDR3 lengths and reduced number of known pathology-associated TCRs.
- Subjects
DNA methylation; DNA repair; T cells; ANTIGEN receptors; IMMUNODEFICIENCY
- Publication
Journal of Clinical Immunology, 2022, Vol 42, Issue 2, p375
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-021-01178-1