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Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
Published in:
PLoS Biology, 2017, v. 15, n. 6, p. 1, doi. 10.1371/journal.pbio.2000784
By:
- Juneja, Manisha;
- Kobelt, Dennis;
- Walther, Wolfgang;
- Voss, Cynthia;
- Smith, Janice;
- Specker, Edgar;
- Neuenschwander, Martin;
- Gohlke, Björn-Oliver;
- Dahlmann, Mathias;
- Radetzki, Silke;
- Preissner, Robert;
- von Kries, Jens Peter;
- Schlag, Peter Michael;
- Stein, Ulrike
Publication type:
Article
Verringerung der Virulenz von multiresistentem Staphylococcus aureus mithilfe eines chemischen Disruptors des ClpX-Chaperon-Komplexes.
Published in:
Angewandte Chemie, 2017, v. 129, n. 49, p. 15952, doi. 10.1002/ange.201708454
By:
- Fetzer, Christian;
- Korotkov, Vadim S.;
- Thänert, Robert;
- Lee, Kyu Myung;
- Neuenschwander, Martin;
- von Kries, Jens Peter;
- Medina, Eva;
- Sieber, Stephan A.
Publication type:
Article
Glycolytic flux control by drugging phosphoglycolate phosphatase.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34228-2
By:
- Jeanclos, Elisabeth;
- Schlötzer, Jan;
- Hadamek, Kerstin;
- Yuan-Chen, Natalia;
- Alwahsh, Mohammad;
- Hollmann, Robert;
- Fratz, Stefanie;
- Yesilyurt-Gerhards, Dilan;
- Frankenbach, Tina;
- Engelmann, Daria;
- Keller, Angelika;
- Kaestner, Alexandra;
- Schmitz, Werner;
- Neuenschwander, Martin;
- Hergenröder, Roland;
- Sotriffer, Christoph;
- von Kries, Jens Peter;
- Schindelin, Hermann;
- Gohla, Antje
Publication type:
Article
Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.
Published in:
EMBO Molecular Medicine, 2018, v. 10, n. 10, p. N.PAG, doi. 10.15252/emmm.201809155
By:
- Otten, Cécile;
- Knox, Jessica;
- Boulday, Gwénola;
- Eymery, Mathias;
- Haniszewski, Marta;
- Neuenschwander, Martin;
- Radetzki, Silke;
- Vogt, Ingo;
- Hähn, Kristina;
- De Luca, Coralie;
- Cardoso, Cécile;
- Hamad, Sabri;
- Igual Gil, Carla;
- Roy, Peter;
- Albiges‐Rizo, Corinne;
- Faurobert, Eva;
- Kries, Jens P;
- Campillos, Mónica;
- Tournier‐Lasserve, Elisabeth;
- Derry, W Brent
Publication type:
Article
A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus.
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 49, p. 15746, doi. 10.1002/anie.201708454
By:
- Fetzer, Christian;
- Korotkov, Vadim S.;
- Thänert, Robert;
- Lee, Kyu Myung;
- Neuenschwander, Martin;
- von Kries, Jens Peter;
- Medina, Eva;
- Sieber, Stephan A.
Publication type:
Article
A simple selection strategy for evolving highly efficient enzymes.
Published in:
Nature Biotechnology, 2007, v. 25, n. 10, p. 1145, doi. 10.1038/nbt1341
By:
- Neuenschwander, Martin;
- Butz, Maren;
- Heintz, Caroline;
- Kast, Peter;
- Hilvert, Donald
Publication type:
Article
Functional Mapping of Protein-Protein Interactions in an Enzyme Complex by Directed Evolution.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0116234
By:
- Roderer, Kathrin;
- Neuenschwander, Martin;
- Codoni, Giosiana;
- Sasso, Severin;
- Gamper, Marianne;
- Kast, Peter
Publication type:
Article
Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.
Published in:
Clinical & Translational Allergy, 2021, v. 11, n. 5, p. 1, doi. 10.1002/clt2.12045
By:
- Bonnekoh, Hanna;
- Vera, Carolina;
- Abad‐Perez, Angela;
- Radetzki, Silke;
- Neuenschwander, Martin;
- Specker, Edgar;
- Mahnke, Niklas Amadeus;
- Frischbutter, Stefan;
- Latz, Eicke;
- Nazaré, Marc;
- Kries, Jens v.;
- Maurer, Marcus;
- Scheffel, Jörg;
- Krause, Karoline
Publication type:
Article
A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy.
Published in:
Thyroid, 2019, v. 29, n. 1, p. 111, doi. 10.1089/thy.2018.0349
By:
- Marcinkowski, Patrick;
- Hoyer, Inna;
- Specker, Edgar;
- Furkert, Jens;
- Rutz, Claudia;
- Neuenschwander, Martin;
- Sobottka, Sebastian;
- Sun, Han;
- Nazare, Marc;
- Berchner-Pfannschmidt, Utta;
- von Kries, Jens Peter;
- Eckstein, Anja;
- Schülein, Ralf;
- Krause, Gerd
Publication type:
Article
The FGFR inhibitor PD173074 binds to the C‐terminus of oncofetal HMGA2 and modulates its DNA‐binding and transcriptional activation functions.
Published in:
FEBS Letters, 2023, v. 597, n. 15, p. 1977, doi. 10.1002/1873-3468.14675
By:
- Ahmed, Syed Moiz;
- Ragunathan, Priya;
- Shin, Joon;
- Peter, Sabrina;
- Kleissle, Sabrina;
- Neuenschwander, Martin;
- Schäfer, Reinhold;
- Kries, Jens Peter V.;
- Grüber, Gerhard;
- Dröge, Peter
Publication type:
Article
Small Molecules Targeting Human UDP‐GlcNAc 2‐Epimerase.
Published in:
ChemBioChem, 2023, v. 24, n. 24, p. 1, doi. 10.1002/cbic.202300555
By:
- Gorenflos López, Jacob L.;
- Dornan, Gillian L.;
- Boback, Nico;
- Neuenschwander, Martin;
- Oder, Andreas;
- Kemnitz‐Hassanin, Kristin;
- Schmieder, Peter;
- Specker, Edgar;
- Asikoglu, Hatice Ceyda;
- Oberdanner, Christian;
- Seyffarth, Carola;
- von Kries, Jens Peter;
- Lauster, Daniel;
- Hinderlich, Stephan;
- Hackenberger, Christian P. R.
Publication type:
Article
Small Molecules Targeting Human N-Acetylmannosamine Kinase.
Published in:
ChemBioChem, 2017, v. 18, n. 13, p. 1279, doi. 10.1002/cbic.201700066
By:
- Hinderlich, Stephan;
- Neuenschwander, Martin;
- Wratil, Paul R.;
- Oder, Andreas;
- Lisurek, Michael;
- Nguyen, Long D.;
- von Kries, Jens P.;
- Hackenberger, Christian P. R.
Publication type:
Article
SLENDER COLUMN STRENGTH OF INNOVATIVE CONCRETE FILLED STEEL TUBE COLUMNS WITH HIGH‐PERFORMANCE BUILDING MATERIALS.
Published in:
CE/Papers, 2023, v. 6, n. 1, p. 219, doi. 10.1002/cepa.1906
By:
- Schurgacz, Przemyslaw;
- Neuenschwander, Martin;
- Knobloch, Markus
Publication type:
Article
7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase.
Published in:
eLife, 2024, p. 1, doi. 10.7554/eLife.93094
By:
- Brenner, Marian;
- Zink, Christoph;
- Witzinger, Linda;
- Keller, Angelika;
- Hadamek, Kerstin;
- Bothe, Sebastian;
- Neuenschwander, Martin;
- Villmann, Carmen;
- von Kries, Jens Peter;
- Schindelin, Hermann;
- Jeanclos, Elisabeth;
- Gohla, Antje
Publication type:
Article
Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4.
Published in:
PLoS ONE, 2024, v. 19, n. 7, p. 1, doi. 10.1371/journal.pone.0302704
By:
- Mohd, Saif;
- Oder, Andreas;
- Specker, Edgar;
- Neuenschwander, Martin;
- Von Kries, Jens Peter;
- Daumke, Oliver
Publication type:
Article
Revealing cytotoxic substructures in molecules using deep learning.
Published in:
Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 7, p. 731, doi. 10.1007/s10822-020-00310-4
By:
- Webel, Henry E.;
- Kimber, Talia B.;
- Radetzki, Silke;
- Neuenschwander, Martin;
- Nazaré, Marc;
- Volkamer, Andrea
Publication type:
Article
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.88982
By:
- Aguirre, Tim;
- Dornan, Gillian L.;
- Hostachy, Sarah;
- Neuenschwander, Martin;
- Seyffarth, Carola;
- Haucke, Volker;
- Schütz, Anja;
- von Kries, Jens Peter;
- Fiedler, Dorothea
Publication type:
Article
Author Correction: Loss-of-function uORF mutations in human malignancies.
Published in:
2021
By:
- Schulz, Julia;
- Mah, Nancy;
- Neuenschwander, Martin;
- Kischka, Tabea;
- Ratei, Richard;
- Schlag, Peter M.;
- Castaños-Vélez, Esmeralda;
- Fichtner, Iduna;
- Tunn, Per-Ulf;
- Denkert, Carsten;
- Klaas, Oliver;
- Berdel, Wolfgang E.;
- von Kries, Jens P.;
- Makalowski, Wojciech;
- Andrade-Navarro, Miguel A.;
- Leutz, Achim;
- Wethmar, Klaus
Publication type:
Correction Notice
Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform.
Published in:
Molecular Diversity, 2014, v. 18, n. 3, p. 483, doi. 10.1007/s11030-014-9518-6
By:
- Wilde, Felix;
- Specker, Edgar;
- Neuenschwander, Martin;
- Nazaré, Marc;
- Bodtke, Anja;
- Link, Andreas
Publication type:
Article
Sustainable synthesis and automated deposition: an accessible discovery screening library of fragment-like purines.
Published in:
Molecular Diversity, 2012, v. 16, n. 3, p. 541, doi. 10.1007/s11030-012-9386-x
By:
- Kamper, Christoph;
- Korpis, Katharina;
- Specker, Edgar;
- Anger, Lennart;
- Neuenschwander, Martin;
- Bednarski, Patrick;
- Link, Andreas
Publication type:
Article
Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP.
Published in:
Cells (2073-4409), 2020, v. 9, n. 3, p. 673, doi. 10.3390/cells9030673
By:
- Dema, Alessandro;
- Faust, Dörte;
- Lazarow, Katina;
- Wippich, Marc;
- Neuenschwander, Martin;
- Zühlke, Kerstin;
- Geelhaar, Andrea;
- Pallien, Tamara;
- Hallscheidt, Eileen;
- Eichhorst, Jenny;
- Wiesner, Burkhard;
- Černecká, Hana;
- Popp, Oliver;
- Mertins, Philipp;
- Dittmar, Gunnar;
- von Kries, Jens Peter;
- Klussmann, Enno
Publication type:
Article
Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.
Published in:
PLoS ONE, 2023, v. 17, n. 2, p. 1, doi. 10.1371/journal.pone.0278325
By:
- Jordan, Philipp;
- Costa, Amanda;
- Specker, Edgar;
- Popp, Oliver;
- Volkamer, Andrea;
- Piske, Regina;
- Obrusnik, Tessa;
- Kleissle, Sabrina;
- Stuke, Kevin;
- Rex, Andre;
- Neuenschwander, Martin;
- von Kries, Jens Peter;
- Nazare, Marc;
- Mertins, Phillip;
- Kettenmann, Helmut;
- Wolf, Susanne A.
Publication type:
Article
Loss-of-function uORF mutations in human malignancies.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-19201-8
By:
- Schulz, Julia;
- Mah, Nancy;
- Neuenschwander, Martin;
- Kischka, Tabea;
- Ratei, Richard;
- Schlag, Peter M.;
- Castaños-Vélez, Esmeralda;
- Fichtner, Iduna;
- Tunn, Per-Ulf;
- Denkert, Carsten;
- Klaas, Oliver;
- Berdel, Wolfgang E.;
- von Kries, Jens P.;
- Makalowski, Wojciech;
- Andrade-Navarro, Miguel A.;
- Leutz, Achim;
- Wethmar, Klaus
Publication type:
Article
Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.
Published in:
PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0208641
By:
- Klein, Wolfgang;
- Rutz, Claudia;
- Eckhard, Jamina;
- Provinciael, Becky;
- Specker, Edgar;
- Neuenschwander, Martin;
- Kleinau, Gunnar;
- Scheerer, Patrick;
- von Kries, Jens-Peter;
- Nazaré, Marc;
- Vermeire, Kurt;
- Schülein, Ralf
Publication type:
Article
Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
Published in:
PLoS ONE, 2018, v. 13, n. 6, p. 1, doi. 10.1371/journal.pone.0198492
By:
- Liss, Martin;
- Radke, Michael H.;
- Eckhard, Jamina;
- Neuenschwander, Martin;
- Dauksaite, Vita;
- von Kries, Jens-Peter;
- Gotthardt, Michael
Publication type:
Article
Onlinesucht - Realität auch ohne offizielle Diagnose.
Published in:
Therapeutische Umschau, 2014, v. 71, n. 10, p. 599, doi. 10.1024/0040-5930/a000559
By:
- Neuenschwander, Martin
Publication type:
Article
Generic Model Stress-Strain Relationship for Concrete in Compression at Elevated Temperatures.
Published in:
ACI Materials Journal, 2017, v. 114, n. 1, p. 3, doi. 10.14359/51689468
By:
- Neuenschwander, Martin;
- Knobloch, Markus;
- Fontana, Mario
Publication type:
Article
An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Published in:
PLoS ONE, 2018, v. 13, n. 1, p. 1, doi. 10.1371/journal.pone.0191423
By:
- Schrade, Katharina;
- Tröger, Jessica;
- Eldahshan, Adeeb;
- Zühlke, Kerstin;
- Abdul Azeez, Kamal R.;
- Elkins, Jonathan M.;
- Neuenschwander, Martin;
- Oder, Andreas;
- Elkewedi, Mohamed;
- Jaksch, Sarah;
- Andrae, Karsten;
- Li, Jinliang;
- Fernandes, Joao;
- Müller, Paul Markus;
- Grunwald, Stephan;
- Marino, Stephen F.;
- Vukićević, Tanja;
- Eichhorst, Jenny;
- Wiesner, Burkhard;
- Weber, Marcus
Publication type:
Article

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