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- Title
Untargeted metabolomic analysis in non-fasted diabetic dogs by UHPLC-HRMS.
- Authors
O'Kell, A. L.; Garrett, T. J.; Wasserfall, C.; Atkinson, M. A.
- Abstract
Introduction: We recently identified variances in serum metabolomic profiles between fasted diabetic and healthy dogs, some having similarities to those identified in human type 1 diabetes.Objectives: Compare untargeted metabolomic profiles in the non-fasted state.Methods: Serum from non-fasted diabetic (n = 6) and healthy control (n = 6) dogs were analyzed by liquid chromatography-high resolution mass spectrometry.Results: Clear clustering of metabolites between groups were observed, with multiple perturbations identified that were similar to those previously observed in fasted diabetic dogs.Conclusion: These findings further support the development of targeted assays capable of detecting metabolites that may be useful as biomarkers of canine diabetes.
- Subjects
METABOLOMICS; TYPE 1 diabetes; LIQUID chromatography; METABOLITE analysis; BIOLOGICAL tags; ANIMAL models of diabetes
- Publication
Metabolomics, 2019, Vol 15, Issue 2, p1
- ISSN
1573-3882
- Publication type
Article
- DOI
10.1007/s11306-019-1477-6