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- Title
Imaging findings of malignant bilateral carotid body tumors: A case report and review of the literature.
- Authors
HAN LV; XIAOHONG CHEN; SHUAI ZHOU; SUPING CUI; YUNLONG BAI; ZHENCHANG WANG
- Abstract
Carotid body tumors (CBTs) are a rare type of extra-adrenal paraganglioma, which originate from the carotid body. A 29-year-old woman was admitted to the Department of Head and Neck Surgery, Beijing Tongren Hospital (Capital Medical University, Beijing, China) with hoarseness of the throat, which had progressively worsened over seven months. The patient had a family history of CBTs. Computed tomography and ultrasound imaging revealed multiple well-enhanced masses located at the bilateral carotid bifurcation and in the left parapharyngeal space. Surgery and pathological examination confirmed that the patient had developed regional lymph node metastasis. Significantly enhanced multiple pulmonary and hepatic lesions indicated that the patient had also developed distal metastasis. A genetic analysis performed on the family members of the patient revealed that the family carried a mutated succinate dehydrogenase D gene. In the present study, a systemic review of the literature indicated that extra vigilance is required in familial forms of CBT, in order to increase the standard of treatment for CBT patients.
- Subjects
CAROTID body tumors; IMAGING of cancer; PARAGANGLIOMA; COMPUTED tomography; METASTASIS; SUCCINATE dehydrogenase
- Publication
Oncology Letters, 2016, Vol 11, Issue 4, p2457
- ISSN
1792-1074
- Publication type
Case Study
- DOI
10.3892/ol.2016.4227