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- Title
Effects of Hepatocyte Growth Factor Injection and Reinjection.
- Authors
Garcia, Roberta Ismael Dias; Tsuhji, Domingos Hiroshi; Imamura, Luiz F.; Bissoli, Rui; Mauad, Thais
- Abstract
Objective: The study sought to assess the effects of HGF injection and reinjection coinciding with its peak of activity on collagen density, vessel density, inflammatory reaction in the lamina propria, and mean epithelial thickness in the injured rabbit vocal fold. Method: Fourteen rabbits were subdivided in group 1 that received HGF injections into the right vocal fold and 2 that received bilateral HGF injections and reinjection into the right vocal fold 10 days after. Left vocal folds were controls. Histological assessment was performed at 30 and 40 days respectively. Results: In both groups, collagen density was lower in the right vocal folds than in the left folds (P =. 018). Vessel density was higher in the right vocal folds in group 2 (P =. 018). Differences about mean epithelial thickness and inflammatory reaction in the lamina propria are not statistical significance. Conclusion: In the scarred rabbit vocal fold, HGF injection is associated with decreased collagen density in the lamina propria, whereas reinjection after 10 days produces decreased collagen density and higher vessel density.
- Subjects
HEPATOCYTE growth factor; VOCAL cords; LABORATORY rabbits
- Publication
Otolaryngology-Head & Neck Surgery, 2011, Vol 145, pP191
- ISSN
0194-5998
- Publication type
Abstract
- DOI
10.1177/0194599811415823a185