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- Title
DHHC8-Dependent PICK1 Palmitoylation is Required for Induction of Cerebellar Long-Term Synaptic Depression.
- Authors
Thomas, Gareth M.; Takashi Hayashi; Huganir, Richard L.; Linden, David J.
- Abstract
The palmitoyl acyltransferase (PAT) DHHC8 is implicated in synaptic regulation but few DHHC8 substrates are known. Here we report that DHHC8 binds and palmitoylates the PDZ domain-containing protein PICK1 at a cysteine residue that is essential for long-term synaptic depression (LTD) in cultured mouse cerebellar Purkinje neurons. Cerebellar LTD is palmitoylation-dependent and induction of LTD requires DHHC8. Furthermore, PICK1 is a critical DHHC8 substrate whose palmitoylation is necessary for LTD. These results identify the first DHHC8 substrate required for a specific form of synaptic plasticity and provide new insights into synaptic roles of palmitoylation.
- Subjects
PALMITOYLATION; ACYLTRANSFERASES; CEREBELLAR cortex; LONG-term synaptic depression; NEUROPLASTICITY
- Publication
Journal of Neuroscience, 2013, Vol 33, Issue 39, p15401
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1283-13.2013