We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Managing multiple myeloma: the emerging role of novel therapies and adapting combination treatment for higher risk settings.
- Authors
Richardson, Paul G.; Laubach, Jacob; Mitsiades, Constantine S.; Schlossman, Robert; Hideshima, Teru; Redman, Katherine; Chauhan, Dharminder; Ghobrial, Irene M.; Munshi, Nikhil; Anderson, Kenneth C.
- Abstract
Summary Novel therapies have transformed the treatment paradigm for multiple myeloma with significant improvements in survival now seen in both younger and older patients. Nonetheless, the disease is heterogeneous and high-risk patients in particular continue to have poor outcome. Moreover, the disease remains incurable. Efforts to refine risk stratification and disease characteristics continue with the use of cytogenetics, enhanced imaging techniques and other new technologies, such as genomics. The integration of novel therapies into induction therapy, consolidation and maintenance continues to evolve, and the appropriate use of combination strategies including proteasome inhibition and immunomodulatory treatment is emerging as a platform with application across the disease spectrum. Despite these advances, resistance to novel agents occurs and so the identification of new targets and the recognition of clonal heterogeneity are especially important as improvements to current treatment strategies are developed, with the goal of further improving patient outcome.
- Subjects
MULTIPLE myeloma treatment; HEALTH outcome assessment; CYTOGENETICS; MEDICAL imaging systems; GENOMICS
- Publication
British Journal of Haematology, 2011, Vol 154, Issue 6, p755
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2011.08791.x