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- Title
ATL>The effect of high dose and short interval HBV vaccination in individuals with chronic hepatitis C.
- Authors
Idilman, Ramazan; De Maria, Nicola; Colantoni, Alessandra; Nadir, Abdul; Van Thiel, David H.
- Abstract
OBJECTIVES:The efficacy of the standard hepatitis B virus (HBV) vaccination schedule in individuals with chronic hepatitis C is reported to be reduced. Our aim was to assess the response rate to high dose, short interval HBV vaccination in such individuals.METHODS:A total of 152 individuals with chronic hepatitis C were vaccinated with 40 μg of vaccine administered monthly for 3 months. Twenty-six individuals with no evidence of liver disease underwent the same vaccination schedule and were considered to be the control group. Hepatitis C virus (HCV)-positive subjects who did not seroconvert to anti-hepatitis B surface positivity after the third dose of the vaccine (nonresponder) were vaccinated with a fourth dose of vaccine (booster dose, 80 μg).RESULTS:One hundred nine of the 152 individuals with chronic hepatitis C (72%) seroconverted to anti-hepatitis B surface positivity (>10 mIU/ml), as compared to 24 of the 26 controls (92%, p < 0.05). Although individuals with chronic hepatitis C responded less frequently to high dose, short interval HBV vaccination than did the controls, no differences in terms of effective immunity (>100 mIU/ml) were evident among the two groups of responders (51% vs 54%). Also, no difference in response was reported between individuals with chronic active hepatitis C and controls (92% vs 80%). The response rate was significantly lower in cirrhotics than in the noncirrhotic group (54% vs 80%, p < 0.001). Besides cirrhosis, no other demographic or bioclinical factor was found to influence the response to vaccination. After the additional booster dose, the overall response was increased to 74% of the cirrhotics and 88% of the noncirrhotics. No major HBV vaccine-related adverse effects were seen.CONCLUSIONS:A high dose, short interval HBV vaccination schedule is safe in individuals with chronic hepatitis C. From these data, it is suggested that a high dose and a short interval between HBV vaccinations may produce an effective and early antibody response in such patients.
- Subjects
HEPATITIS B virus; HEPATITIS vaccines
- Publication
American Journal of Gastroenterology (Springer Nature), 2002, Vol 97, Issue 2, p435
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2002.05482.x