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- Title
Persistent polyclonal B-cell lymphocytosis--an important differential diagnosis of B-cell chronic lymphocytic leukemia.
- Authors
Reimer, P.; Weißinger, F.; Tony, H.-P.; Koniczek, K.-H.; Wilhelm, M.; Weissinger, F
- Abstract
Over the last 17 years, 83 cases of polyclonal B-cell lymphocytosis (PPBL) have been published. This rare hematological disorder of unknown etiology is characterized by morphologically atypical lymphocytes, polyclonal immunoglobulin M production in association with smoking, female gender, and HLA-DR7 phenotype. We studied another male patient with PPBL. In contrast to normal B-cells, PPBL cells showed no response to interleukin-4 with regard to CD23 and human leukocyte antigen-DR expression. F2mu antibodies failed to co-stimulate interleukin-4-mediated CD23 expression. Crosslinking membrane immunoglobulin M receptors by F2mu resulted in elevated human leukocyte antigen-DR expression but did not induce in vitro proliferation of PPBL cells. This indicates a different activation and differentiation status than normal B-cells.
- Subjects
CELLS; IMMUNOGLOBULINS; INTERLEUKINS; LEUCOCYTES; LYMPHOCYTES; GENETICS; CHRONIC lymphocytic leukemia diagnosis; B cells; CHRONIC lymphocytic leukemia; DIFFERENTIAL diagnosis; LEUCOCYTE disorders
- Publication
Annals of Hematology, 2000, Vol 79, Issue 6, p327
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s002779900144