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Retarded Axonal Transport of R406W Mutant Tau in Transgenic Mice with a Neurodegenerative Tauopathy.
Published in:
Journal of Neuroscience, 2004, v. 24, n. 19, p. 4657, doi. 10.1523/JNEUROSCI.0797-04.2004
By:
- Bin Zhang;
- Higuchi, Makoto;
- Yoshiyama, Yasumasa;
- Ishihara, Takeshi;
- Forman, Mark S.;
- Martinez, Dan;
- Joyce, Sonali;
- Trojanowski, John Q.;
- Lee, Virginia M.-Y.
Publication type:
Article
Proteasome Inhibition Stabilizes Tau Inclusions in Oligodendroglial Cells that Occur after Treatment with Okadaic Acid.
Published in:
Journal of Neuroscience, 2003, v. 23, n. 26, p. 8872, doi. 10.1523/JNEUROSCI.23-26-08872.2003
By:
- Goldbaum, Olaf;
- Oppermann, Malte;
- Handschuh, Melanie;
- Dabir, Deepa;
- Bin Zhang;
- Forman, Mark S.;
- Trojanowski, John Q.;
- Lee, Virginia M.-Y.;
- Richter-Landsberg, Christiane
Publication type:
Article
P2‐002: AN INTEGRATED MECHANISTIC AMYLOID PATHWAY MODEL INFORMED BY CLINICAL BIOMARKER DATA FROM VERUBECESTAT AND OTHER BACE INHIBITORS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P571, doi. 10.1016/j.jalz.2019.06.1224
By:
- Rasmussen, Christian;
- Kleijn, Huub Jan;
- Kalinina, Juliya;
- Dockendorf, Marissa;
- Savage, Mary J.;
- Struyk, Arie;
- Forman, Mark;
- Stone, Julie A.
Publication type:
Article
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs.
Published in:
Nature Medicine, 2004, v. 10, n. 10, p. 1055, doi. 10.1038/nm1113
By:
- Forman, Mark S.;
- Trojanowski, John Q.;
- Lee, Virginia M-Y.
Publication type:
Article
ACUTE ADMINISTRATION OF A BACE INHIBITOR IN HEALTHY HUMANS RESULTS IN A SIGNIFICANT REDUCTION OF Aβ OLIGOMERS IN CEREBROSPINAL FLUID.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P574, doi. 10.1016/j.jalz.2017.07.192
By:
- Kalinina, Juliya;
- Cheon, Kyeongmi;
- Stone, Julie;
- Kennedy, Matthew;
- Forman, Mark;
- Egan, Michael F.;
- Tanen, Michael R.;
- Winrow, Christopher J.;
- Savage, Mary J.
Publication type:
Article
IS THE PERIPHERAL SINK HYPOTHESIS PHYSIOLOGICALLY FEASIBLE? EVIDENCE FROM MODEL-BASED ASSESSMENT OF THE AMYLOID PATHWAY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P443, doi. 10.1016/j.jalz.2016.06.855
By:
- Stone, Julie A.;
- Parker, Eric;
- Kleijn, Huub Jan;
- Forman, Mark;
- Egan, Michael;
- Rowland, Malcolm;
- Potter, William
Publication type:
Article
EARLY CLINICAL RESULTS AND PRECLINICAL VALIDATION OF THE O-GLCNACASE (OGA) INHIBITOR MK-8719 AS A NOVEL THERAPEUTIC FOR THE TREATMENT OF TAUOPATHIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P261, doi. 10.1016/j.jalz.2016.06.469
By:
- Smith, Sean M.;
- Struyk, Arie;
- Jonathan, Daniel;
- Declercq, Ruben;
- Marcus, Jacob;
- Toolan, Dawn;
- Wang, Xiaohai;
- Schachter, Joel B.;
- Cosden, Mali;
- Pearson, Michelle;
- Hess, Fred;
- Selnick, Harold;
- Salinas, Cristian;
- Li, Wenping;
- Duffy, Joseph;
- McEachern, Ernest;
- Vocadlo, David;
- Renger, John J.;
- Eric, Hostetler D.;
- Forman, Mark
Publication type:
Article
EVIDENCE FROM MODEL-BASED ASSESSMENTS OF COMPOUNDS TESTED IN COMPLETED CLINICAL TRIALS INDICATES THAT THE AMYLOID HYPOTHESIS HAS NOT BEEN ADEQUATELY TESTED.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P609, doi. 10.1016/j.jalz.2016.06.1209
By:
- Stone, Julie A.;
- Kleijn, Huub Jan;
- Dockendorf, Marissa;
- Mo, Yi;
- Egan, Michael;
- Forman, Mark
Publication type:
Article
The novel BACE inhibitor MK-8931 dramatically lowers cerebrospinal fluid Aβ peptides in healthy subjects following single- and multiple-dose administration
Published in:
2012
By:
- Forman, Mark;
- Palcza, John;
- Tseng, Jack;
- Leempoels, Jos;
- Ramael, Steven;
- Han, David;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Tanen, Michael;
- Laterza, Omar;
- Dockendorf, Marissa;
- Krishna, Gopal;
- Ma, Lei;
- Wagner, John;
- Troyer, Matthew
Publication type:
Abstract
Development and application of a mathematical model of modulation of cerebrospinal fluid Aβ40 after treatment with gamma- and beta-secretase inhibitors
Published in:
2012
By:
- Kleijn, Huub Jan;
- Ma, Lei;
- Dockendorf, Marissa;
- de Greef, Rik;
- Palcza, John;
- Egan, Michael;
- Forman, Mark;
- Stone, Julie
Publication type:
Abstract
Population pharmacokinetic modeling of the novel BACE inhibitor MK-8931 following single and multiple dose administration in healthy subjects
Published in:
2012
By:
- Ma, Lei;
- Dockendorf, Marissa;
- Krishna, Gopal;
- Kleijn, Huub-Jan;
- Su, Jing;
- Forman, Mark;
- Stone, Julie
Publication type:
Abstract
Safety and pharmacokinetics of the novel BACE inhibitor MK-8931 in healthy subjects following single- and Multiple-Dose administration
Published in:
2012
By:
- Tseng, Jack;
- Dockendorf, Marissa;
- Krishna, Gopal;
- Ma, Lei;
- Palcza, John;
- Leempoels, Jos;
- Ramael, Steven;
- Han, David;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Wagner, John;
- Troyer, Matthew;
- Forman, Mark
Publication type:
Abstract
A study to evaluate the pharmacokinetics and pharmacodynamics of single and multiple oral doses of the novel BACE inhibitor MK-8931 in Japanese subjects
Published in:
2012
By:
- Min, K.;
- Forman, Mark;
- Dockendorf, Marissa;
- Palcza, John;
- Soni, Peter;
- Ma, Lei;
- Krishna, Gopal;
- Hodsman, Peter;
- Masuo, Kazuko;
- Tanen, Michael;
- Wagner, John;
- Troyer, Matthew
Publication type:
Abstract
Development of the amyloid PET radioligand [<sup>18</sup>F]MK-3328
Published in:
2010
By:
- Sanabria-Bohorquez, Sandra;
- Van Laere, Koen;
- Koole, Michel;
- Bormans, Guy;
- Serdons, Kim;
- de Hoon, Jan;
- Vandenberghe, Rik;
- De Lepeleire, Inge;
- Reynders, Tom;
- Zeng, Zhizhen;
- Williams, David;
- Rosen, Laura;
- Hargreaves, Richard;
- Sur, Cyrille;
- Forman, Mark;
- Hostetler, Eric
Publication type:
Abstract
P2-185: FTLD-U–linked missense mutations in VCP/p97 alter localization of endogenous TDP-43 and induce cell death
Published in:
2008
By:
- Gitcho, Michael A.;
- Strider, Jeffrey;
- Carter, Deborah;
- Taylor-Reinwald, Lisa;
- Forman, Mark S.;
- Morris, John C.;
- Goate, Alison M.;
- Cairns, Nigel J.
Publication type:
Abstract
P2-207: Cortical biochemical markers of mild cognitive impairment
Published in:
2006
By:
- Forman, Mark S.;
- Leurgans, Sue;
- Pratico, Domenico;
- Joyce, Sonali;
- Leight, Susan;
- Mufson, Elliott J.;
- Lee, Virginia M.-Y.;
- Trojanowski, John Q.
Publication type:
Abstract
O2-01-03: Impaired glutamate transport and excitotoxicity in a mouse model of tau pathology in astrocytes
Published in:
2006
By:
- Forman, Mark S.;
- Dabir, Deepa;
- Robinson, Michael B.;
- Swanson, Eric;
- Zhang, Bin;
- Trojanowski, John Q.;
- Lee, Virginia M.-Y.
Publication type:
Abstract
P2-207: Cortical biochemical markers of mild cognitive impairment
Published in:
2006
By:
- Forman, Mark S.;
- Leurgans, Sue;
- Pratico, Domenico;
- Joyce, Sonali;
- Leight, Susan;
- Mufson, Elliott J.;
- Lee, Virginia M.-Y.;
- Trojanowski, John Q.
Publication type:
Abstract
O2-01-03: Impaired glutamate transport and excitotoxicity in a mouse model of tau pathology in astrocytes
Published in:
2006
By:
- Forman, Mark S.;
- Dabir, Deepa;
- Robinson, Michael B.;
- Swanson, Eric;
- Zhang, Bin;
- Trojanowski, John Q.;
- Lee, Virginia M.-Y.
Publication type:
Abstract
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.
Published in:
Scientific Reports, 2016, p. 27147, doi. 10.1038/srep27147
By:
- Gotter, Anthony L.;
- Forman, Mark S.;
- Harrell, Charles M.;
- Stevens, Joanne;
- Svetnik, Vladimir;
- Yee, Ka Lai;
- Li, Xiaodong;
- Roecker, Anthony J.;
- Fox, Steven V.;
- Tannenbaum, Pamela L.;
- Garson, Susan L.;
- Lepeleire, Inge De;
- Calder, Nicole;
- Rosen, Laura;
- Struyk, Arie;
- Coleman, Paul J.;
- Herring, W. Joseph;
- Renger, John J.;
- Winrow, Christopher J.
Publication type:
Article
The Alienated Resident and the Alienating Institution: A Case for Peer Group Intervention.
Published in:
Social Work, 1971, v. 16, n. 2, p. 47, doi. 10.1093/sw/16.2.47
By:
- Forman, Mark
Publication type:
Article
Conflict, Controversy, and Confrontation in Group Work with Older Adults.
Published in:
Social Work, 1967, v. 12, n. 1, p. 80
By:
- Forman, Mark
Publication type:
Article
Effect of tubing condensate on non-invasive positive pressure ventilators tested under simulated clinical conditions.
Published in:
Sleep & Breathing, 2011, v. 15, n. 3, p. 535, doi. 10.1007/s11325-010-0397-5
By:
- Hart, Diana;
- Forman, Mark;
- Veale, Andrew
Publication type:
Article
Palatability and Swallowability of Pimavanserin When Mixed with Selected Food Vehicles: An Exploratory Open-Label Crossover Study.
Published in:
Geriatrics (2308-3417), 2021, v. 6, n. 2, p. 1, doi. 10.3390/geriatrics6020061
By:
- Forman, Mark;
- Kouassi, Alex;
- Brandt, Teresa;
- Barsky, Lee;
- Zamora, Cynthia;
- Dekarske, Daryl
Publication type:
Article
TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 22, p. 7729, doi. 10.1523/JNEUROSCI.5894-09.2010
By:
- Ritson, Gillian P.;
- Custer, Sara K.;
- Freibaum, Brian D.;
- Guinto, Jake B.;
- Geffel, Dyanna;
- Moore, Jennifer;
- Waixing Tang;
- Winton, Matthew J.;
- Neumann, Manuela;
- Trojanowski, John Q.;
- Lee, Virginia M.-Y.;
- Forman, Mark S.;
- Taylor, J. Paul
Publication type:
Article
Impaired Glutamate Transport in a Mouse Model of Tau Pathology in Astrocytes.
Published in:
Journal of Neuroscience, 2006, v. 26, n. 2, p. 644, doi. 10.1523/JNEUROSCI.3861-05.2006
By:
- Dabir, Deepa V.;
- Robinson, Michael B.;
- Swanson, Eric;
- Bin Zhang;
- Trojanowski, John Q.;
- Lee, Virginia M.-Y.;
- Forman, Mark S.
Publication type:
Article
Axonal Degeneration Induced by Targeted Expression of Mutant Human Tau in Oligodendrocytes of Transgenic Mice That Model Glial Tauopathies.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 41, p. 9434, doi. 10.1523/JNEUROSCI.2691-05.2005
By:
- Higuchi, Makoto;
- Bin Zhang;
- Forman, Mark S.;
- Yoshiyama, Yasumasa;
- Trojanowski, John Q.;
- Lee, Virginia M.-Y.
Publication type:
Article
Transgenic Mouse Model of Tau Pathology in Astrocytes Leading to Nervous System Degeneration.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 14, p. 3539, doi. 10.1523/JNEUROSCI.0081-05.2005
By:
- Forman, Mark S.;
- Lal, Devika;
- Bin Zhang;
- Dabir, Deepa V.;
- Swanson, Eric;
- Lee, Virginia M.-Y.;
- Trojanowski, John Q.
Publication type:
Article
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Published in:
Acta Neuropathologica, 2009, v. 117, n. 2, p. 137, doi. 10.1007/s00401-008-0477-9
By:
- Neumann, Manuela;
- Kwong, Linda;
- Lee, Edward;
- Kremmer, Elisabeth;
- Flatley, Andrew;
- Yan Xu;
- Forman, Mark;
- Troost, Dirk;
- Kretzschmar, Hans;
- Trojanowski, John;
- Lee, Virginia
Publication type:
Article
Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy.
Published in:
Acta Neuropathologica, 2007, v. 114, n. 1, p. 55, doi. 10.1007/s00401-007-0224-7
By:
- Guinto, Jake;
- Ritson, Gillian;
- Taylor, J.;
- Forman, Mark
Publication type:
Article
Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual.
Published in:
Acta Neuropathologica, 2007, v. 113, n. 4, p. 471, doi. 10.1007/s00401-006-0155-8
By:
- Van Deerlin, Vivianna;
- Forman, Mark;
- Farmer, Jennifer;
- Grossman, Murray;
- Joyce, Sonali;
- Crowe, Alex;
- Trojanowski, John;
- Lee, Virginia;
- Chatterjee, Anjan
Publication type:
Article
Co-occurrence of Parkinson's disease with progressive supranuclear palsy.
Published in:
Acta Neuropathologica, 2002, v. 103, n. 5, p. 526, doi. 10.1007/s00401-001-0483-7
By:
- Judkins, Alexander R.;
- Forman, Mark S.;
- Uryu, Kunihiro;
- Hinkle, David A.;
- Asbury, Arthur K.;
- Lee, Virginia M.-Y.;
- Trojanowski, John Q.
Publication type:
Article
An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter.
Published in:
Alzheimer's Research & Therapy, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13195-015-0136-z
By:
- Lucey, Brendan P.;
- Gonzales, Celedon;
- Das, Ujjwas;
- Jinhe Li;
- Siemers, Eric R.;
- Slemmon, J. Randall;
- Bateman, Randall J.;
- Yafei Huang;
- Fox, Gerard B.;
- Claassen, Jurgen A. H. R.;
- Slats, Diane;
- Verbeek, Marcel M.;
- Gary Tong;
- Soares, Holly;
- Savage, Mary J.;
- Kennedy, Matthew;
- Forman, Mark;
- Sjögren, Magnus;
- Margolin, Richard;
- Xia Chen
Publication type:
Article
Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Published in:
Annals of Neurology, 2007, v. 61, n. 5, p. 427, doi. 10.1002/ana.21147
By:
- Ian R. A. Mackenzie;
- Eileen H. Bigio;
- Paul G. Ince;
- Felix Geser;
- Manuela Neumann;
- Nigel J. Cairns;
- Linda K. Kwong;
- Mark S. Forman;
- John Ravits;
- Heather Stewart;
- Andrew Eisen;
- Leo McClusky;
- Hans A. Kretzschmar;
- Camelia M. Monoranu;
- J. Robin Highley;
- Janine Kirby;
- Teepu Siddique;
- Pamela J. Shaw;
- Virginia M‐Y. Lee;
- John Q. Trojanowski
Publication type:
Article
Frontotemporal dementia: clinicopathological correlations.
Published in:
2006
By:
- Forman MS;
- Farmer J;
- Johnson JK;
- Clark CM;
- Arnold SE;
- Coslett HB;
- Chatterjee A;
- Hurtig HI;
- Karlawish JH;
- Rosen HJ;
- Van Deerlin V;
- Lee VM;
- Miller BL;
- Trojanowski JQ;
- Grossman M;
- Forman, Mark S;
- Farmer, Jennifer;
- Johnson, Julene K;
- Clark, Christopher M;
- Arnold, Steven E
Publication type:
journal article
Frontotemporal dementia: Clinicopathological correlations.
Published in:
Annals of Neurology, 2006, v. 59, n. 6, p. 952
By:
- Mark S. Forman;
- Jennifer Farmer;
- Julene K. Johnson;
- Christopher M. Clark;
- Steven E. Arnold;
- H. Branch Coslett;
- Anjan Chatterjee;
- Howard I. Hurtig;
- Jason H. Karlawish;
- Howard J. Rosen;
- Vivianna Van Deerlin;
- Virginia M.‐Y. Lee;
- Bruce L. Miller;
- John Q. Trojanowski;
- Murray Grossman
Publication type:
Article
Pharmacokinetics and Pharmacodynamics of the BACE1 Inhibitor Verubecestat (MK‐8931) in Healthy Japanese Adults: A Randomized, Placebo‐Controlled Study.
Published in:
Clinical Pharmacology & Therapeutics, 2019, v. 105, n. 5, p. 1234, doi. 10.1002/cpt.1258
By:
- Chris Min, K.;
- Dockendorf, Marissa F.;
- Palcza, John;
- Tseng, Jack;
- Ma, Lei;
- Stone, Julie A.;
- Kleijn, Huub J.;
- Tanen, Michael;
- Troyer, Matthew D.;
- Vugt, Marianne;
- Forman, Mark S.;
- Hodsman, Peter;
- Masuo, Kazuko
Publication type:
Article
Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with <sup>18</sup>F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles.
Published in:
Journal of Nuclear Medicine, 2019, v. 60, n. 1, p. 107, doi. 10.2967/jnumed.118.208215
By:
- Lohith, Talakad G.;
- Bennacef, Idriss;
- Vandenberghe, Rik;
- Vandenbulcke, Mathieu;
- Salinas, Cristian A.;
- Declercq, Ruben;
- Reynders, Tom;
- Telan-Choing, N. Florestina;
- Riffel, Kerry;
- Celen, Sofie;
- Serdons, Kim;
- Bormans, Guy;
- Tsai, Kuenhi;
- Walji, Abbas;
- Hostetler, Eric D.;
- Evelhoch, Jeffrey L.;
- Van Laere, Koen;
- Forman, Mark;
- Stoch, Aubrey;
- Sur, Cyrille
Publication type:
Article
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Published in:
FASEB Journal, 2007, v. 21, n. 5, p. A25, doi. 10.1096/fasebj.21.5.a25
By:
- Forman, Mark S.;
- Mackenzie, Ian R.;
- Cairns, Nigel J.;
- Boyer, Philip J.;
- Markesbery, William R.;
- Neumann, Manuela
Publication type:
Article
Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects.
Published in:
CTS: Clinical & Translational Science, 2019, v. 12, n. 5, p. 545, doi. 10.1111/cts.12645
By:
- Forman, Mark;
- Palcza, John;
- Tseng, Jack;
- Stone, Julie A.;
- Walker, Brittany;
- Swearingen, Dennis;
- Troyer, Matthew D.;
- Dockendorf, Marissa F.
Publication type:
Article
Integral Spirituality: A Startling New Role for Religion in the Modern and Postmodern World.
Published in:
2007
By:
- Forman, Mark
Publication type:
Book Review
Subthalamic nucleus deep brain stimulation in a patient with levodopa-responsive multiple system atrophy.
Published in:
Journal of Neurosurgery, 2004, v. 100, n. 3, p. 553, doi. 10.3171/jns.2004.100.3.0553
By:
- Chou, Kelvin L.;
- Forman, Mark S.;
- Trojanowski, John Q.;
- Hurtig, Howard I.;
- Baltuch, Gordon H.
Publication type:
Article
Bilateral subthalamic nucleus deep brain stimulation for advanced PD: Correlation of intraoperative MER and postoperative MRI with neuropathological findings.
Published in:
Movement Disorders, 2003, v. 18, n. 9, p. 1062, doi. 10.1002/mds.10489
By:
- Counelis, George J.;
- Simuni, Tanya;
- Forman, Mark S.;
- Jaggi, Jurg L.;
- Trojanowski, John Q.;
- Baltuch, Gordon H.
Publication type:
Article
A False Aneurysm of the Proximal Common Carotid Artery: Evaluation and Management--A Case Report.
Published in:
Vascular Surgery, 1993, v. 27, n. 4, p. 320, doi. 10.1177/153857449302700414
By:
- Kiev, Jonathan;
- Forman, Mark H.;
- Kerstein, Morris D.
Publication type:
Article
Hypotensive Blood Flow in Six Millimeter and Eight Millimeter PTFE Arterio-Venous Fistulas.
Published in:
Vascular Surgery, 1984, v. 18, n. 2, p. 67, doi. 10.1177/153857448401800201
By:
- Forman, Mark;
- Doscher, William;
- Stein, Theodore;
- Wise, Leslie
Publication type:
Article

Found: 45