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- Title
Purification and Identification of Antitumor Secondary Metabolites from Soil Streptomyces sp. 2215.
- Authors
HUANG Lin; XU Yan-wei; KUANG Yan-wei; ZHANG Qin-lin; WU Zu-ze
- Abstract
Streptomyces sp. 2215 was fermented in fermentation tank, and the broth was extracted with EtOAc and purified by silica chromatography, C18 chromatography, Sephadex LH-20, preparative TLC and HPLC. Four compounds were isolated and identified to be monosulfoxide quinomycine (1), echinomycin (quinomycine A.2) ,2-quinoxalinecarboxylic acid (3), palmitic acid (4) by IR, FAB-MS, ¹H,13 C NMR, ¹H-¹H COSY, HSQC, HMBC etc. Compounds 1 and 2 showed inhibitory, activity on the growth of K562 cells with IC50 34.0 and 1.5 ng/mL respectively by MTT assay in vitro.
- Subjects
STREPTOMYCES; METABOLITES; ANTINEOPLASTIC agents; PALMITIC acid; THIN layer chromatography; HIGH performance liquid chromatography
- Publication
Natural Product Research & Development, 2009, Vol 21, Issue 2, p235
- ISSN
1001-6880
- Publication type
Article