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- Title
The Interactive Effect of Prepregnancy Overweight/Obesity and Isolated Maternal Hypothyroxinemia on Macrosomia.
- Authors
Yindi Liu; Fei Guo; Yulai Zhou; Xi Yang; Yong Zhang; Jianxia Fan; Liu, Yindi; Guo, Fei; Zhou, Yulai; Yang, Xi; Zhang, Yong; Fan, Jianxia
- Abstract
<bold>Context: </bold>Prepregnancy overweight/obesity (OWO) and isolated maternal hypothyroxinemia (IMH) may increase the risk of macrosomia, but little is known about their potential combined effect on macrosomia.<bold>Objective: </bold>The aim of this study was to assess whether prepregnancy OWO and first-trimester IMH have a synergistic effect on the risk of macrosomia.<bold>Methods: </bold>A large prospective cohort study in a Chinese population from January 2016 to December 2018 in a tertiary care center. In total, 34 930 pregnant women were included. The main outcome measure was macrosomia.<bold>Results: </bold>A total of 34 930 participants comprising IMH and euthyroid cases was included in this study. Prepregnancy OWO and first-trimester IMH were independently associated with an increased risk of macrosomia (adjusted odds ratio [OR] 2.48, 95% CI 2.22, 2.78, and adjusted OR 1.65, 95% CI 1.34, 2.01, respectively). The coexistence of prepregnancy OWO and IMH was associated with macrosomia, with an adjusted OR of 5.26 (95% CI 3.9, 7.0) compared with pregnant women without either condition. The additive interaction between prepregnancy OWO and IMH was found to be significant with regard to macrosomia.<bold>Conclusion: </bold>Prepregnancy OWO and IMH in the first trimester may synergistically increase the risk of macrosomia.
- Subjects
CHINA; FETAL macrosomia; HYPOTHYROIDISM; OBESITY; MEDICAL sciences; MEDICAL research; MEDICAL personnel; RESEARCH; BODY weight; THYROXINE; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; PREGNANCY complications; LONGITUDINAL method; DISEASE complications
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 7, pe2639
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgab171