We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
全原子分子動力学計算が解き明かす分子モーターの回転機構.
- Authors
Itō Yūko; Ikeguchi Mitsunori
- Abstract
In the F1-ATPase complex, the conformational change of the catalytically active β subunit is propagated to the entire α3β3 ring, resulting in an asymmetry in the hexamer. With the sequential nucleotide perturbations, the asymmetrical α3β3 structure changes from one state to the other, which rotates the γ subunit axis. Basically, the two elements: the β structural change and the asymmetrical α3β3 are essential for the molecular motor rotation. Therefore, we have been studying them using molecular dynamics (MD) simulations. The results in a series of our studies deepen the understanding of the rotational mechanism of the motor.
- Publication
Seibutsu Butsuri, 2015, Vol 55, Issue 1, p23
- ISSN
0582-4052
- Publication type
Article
- DOI
10.2142/biophys.55.023