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- Title
Association of coronary artery disease severity and disulphide/native thiol ratio.
- Authors
Bilir, Bulent; Cayan Akkoyun, Dursun; Aydın, Murat; Ozkaramanlı Gur, Demet; Değirmenci, Hasan; Albayrak, Neslihan; Akyuz, Aydın; Alpsoy, Seref; Koca, Cemile; Erel, Ozcan
- Abstract
Objective: Oxidative stress is among the major components of cardiovascular disease pathogenesis. Thiols play a significant role in prevention of oxidative stress in the cell. The purpose of this study is to investigate the relationship between the severity of coronary artery disease and disulphide/native thiol ratio, also determine if this ratio can be used as a marker of oxidative stress in this population. Methods: A total number of 107 patients with angiographically established coronary artery disease and 26 control subjects with normal coronary arteries were enrolled. The mean Gensini score of patients were calculated (mean=30) and a score of 29 or below was considered as mild and a score of 30 or higher coronary artery disease as severe. Serum total, native thiol was measured and the disulphide and disulphide/native thiol ratio were calculated as described by Erel&Neselioglu. Results: Patients with mild and severe coronary artery disease had significantly lower native thiol levels and higher disulphide/native thiol ratio levels when compared to the control subjects. Also severe disease's disulphide/native thiol ratio were higher than mild. Conclusion: The increased disulphide/native thiol ratio related with the severity of coronary artery disease, may reflect the augmented oxidative stress in coronary artery disease.
- Subjects
BIOMARKERS; COMPARATIVE studies; CORONARY disease; SULFUR compounds; OXIDATIVE stress; SEVERITY of illness index
- Publication
European Journal of General Medicine, 2017, Vol 14, Issue 2, p30
- ISSN
1304-3889
- Publication type
Article
- DOI
10.29333/ejgm/81878