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- Title
Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~.
- Authors
Tsutsumi, Takeshi; Komura, Kazumasa; Hashimoto, Takeshi; Muraoka, Ryu; Satake, Naoya; Matsunaga, Tomohisa; Tsujino, Takuya; Yoshikawa, Yuki; Takai, Tomoaki; Minami, Koichiro; Taniguchi, Kohei; Tanaka, Tomohito; Uehara, Hirofumi; Hirano, Hajime; Nomi, Hayahito; Ibuki, Naokazu; Takahara, Kiyoshi; Inamoto, Teruo; Ohno, Yoshio; Azuma, Haruhito
- Abstract
<bold>Background: </bold>We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy.<bold>Methods: </bold>A total of 665 patients who underwent nephrectomy for localized RCC were enrolled in the present study and divided into the two BMI groups: i.e., BMI < 25 in 463 (69.6%) and BMI > 25 in 202 (30.4%) patients.<bold>Results: </bold>In total, there were 482 (72.5%) males and 183 (27.5%) females. Five-year cancer-specific survival (CSS) rates were significantly higher in increased BMI than the lower BMI group (97.1 and 92.5%: P = 0.007). When stratified by sex, significantly longer CSS in higher BMI was confirmed in males (5-year CSS of 92.7% in BMI < 25 and 98.1% in BMI > 25, p = 0.005), while there was no difference in CSS between BMI groups for female patients. Multivariable analysis exhibited that higher BMI was an independent predictor for favorable CSS in male (cox model: p = 0.041, Fine & Gray regression model: p = 0.014), but not in the female. Subgroup analysis for CSS revealed that favorable CSS with higher BMI was observed in patient subgroups of age < 65 (p = 0.019), clear cell histology (p = 0.018), and tumor size > 4 cm, p = 0.020) as well as male (p = 0.020).<bold>Conclusion: </bold>Our findings collected from the multi-institutional Japanese dataset demonstrated longer survival in patients with higher BMI than lower BMI for non-metastatic RCC treated with nephrectomy. Intriguingly, this finding was restricted to males, but not to females.
- Subjects
JAPAN; BODY mass index; RENAL cell carcinoma; PROGNOSIS; NEPHRECTOMY
- Publication
BMC Cancer, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-021-07883-9