We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma.
- Authors
Habib, Nagy; Salama, Hosny; Abd El Latif Abu Median, Ahmed; Isac Anis, Ilia; Abd Al Aziz, Rasha Ahmed; Sarraf, Catherine; Mitry, Ragai; Havlik, Roman; Seth, Prem; Hartwigsen, Jack; Bhushan, Reva; Nicholls, Joanna; Jensen, Steen
- Abstract
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The prognosis of HCC is poor and current therapies are largely ineffective. Genetic abnormalities are commonly seen in HCC tumors particularly with inactivation of the p53 tumor suppressor. Gene therapy with E1B-deleted (dl1520) adenovirus could be of therapeutic value as it offers the potential of tumor growth control in patients with p53 mutation. Ten patients with posthepatitis cirrhosis and histologically proven HCC were enrolled into an open label, randomized prospective study. Randomization was to receive either percutaneous ethanol injection (control group) or dl1520. Toxicity and complications in the ethanol group were pain and fever, whereas in the gene therapy group complications were minimal. Grade I-II toxicity fever, stable performance status, and no significant rise in liver enzymes were observed in patients treated with dl1520. Analysis of patients' response to treatment in the gene therapy group showed one patient with a partial response and four patients with progressive disease. In the ethanol-treated group two patients had stable disease and three patients showed disease progression. In conclusion, this study showed that the adenovirus was well tolerated, but did not seem to offer significant tumor control. Although only a small number of patients were treated here it appears that more effective vectors are needed to achieve a useful clinical impact.
- Subjects
LIVER cancer; TUMORS
- Publication
Cancer Gene Therapy, 2002, Vol 9, Issue 3, p254
- ISSN
0929-1903
- Publication type
Article
- DOI
10.1038/sj.cgt.7700431