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- Title
Neoadjuvant imatinib in a gastrointestinal stromal tumor of the rectum: Report of a case.
- Authors
Yuma Ebihara; Shunichi Okushiba; You Kawarada; Shuji Kitashiro; Hiroyuki Katoh; Satoshi Kondo
- Abstract
Abstract Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal tract, and of these, GISTs involving the rectum are uncommon. This report describes a case of effective neoadjuvant therapy for a rectal GIST expressing the c-kit gene, where a laparoscopic ultralow anterior resection was successfully performed, thus preserving the anus. A 57-year-old woman visited our hospital due to constipation and was found by a digital examination to have a soft mass on the right wall of the rectum. Computed tomography revealed an 8.0 × 5.0-cm mass with an unclear margin adjacent to the rectum. A biopsy specimen was positive for CD34 and the c-kit gene product, but it was not positive for smooth muscle actin or S-100 protein, and thus the tumor was diagnosed as GIST. An abdominoperineal resection is generally essential for large rectal GISTs; however, she refused this operation. Neoadjuvant treatment with Imatinib decreased the tumor size (4.0 × 3.5 cm) and the anus was preserved by a laparoscopic ultralow anterior resection with direct coloanal anastomosis. She had no evidence of disease for 24 months postoperatively. To preserve the anus, a rectal GIST expressing the c-kit gene is best treated with Imatinib as neoadjuvant therapy.
- Subjects
ADJUVANT treatment of cancer; GASTROINTESTINAL tumors; LAPAROSCOPY; LAPAROSCOPIC surgery; CANCER treatment
- Publication
Surgery Today, 2008, Vol 38, Issue 2, p174
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-007-3585-6