We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Serum and aqueous humor vitamin D levels in patients with diabetic macular edema.
- Authors
Kim, Kyoung Lae; Moon, Su Young; Noh, Hye-Mi; Park, Sung Pyo; Kim, Yong-Kyu
- Abstract
Purpose: To compare serum and aqueous humor (AH) vitamin D levels between the patients with diabetic macular edema (DME) and controls. Methods: A total of 65 subjects (30 DME, 35 control) were included. One-third of the control group had hypertension, dyslipidemia, or diabetes mellitus without diabetic retinopathy as underlying diseases. Serum and AH levels of 25-hydroxyvitamin D were measured in each subject. Multiple linear regression analysis was performed to investigate factors associated with serum and AH vitamin D levels. Results: There were no significant differences in serum vitamin D levels between the DME (14.3 ± 9.1 ng/mL) and control (16.2 ± 8.0 ng/mL) groups (P = 0.374). However, eyes with DME (41.6 ± 8.0 ng/mL) had a higher AH level of vitamin D than control eyes (25.5 ± 4.1 ng/mL, P < 0.001). AH vitamin D level was significantly associated with the presence of DME (β = 0.775, P < 0.001). Serum and AH levels of vitamin D were not significantly correlated (r = − 0.157, P = 0.211). Conclusion: Serum vitamin D levels did not significantly differ between the DME and control groups. Localized vitamin D level in the eye was independent from systemic vitamin D level and it might be another indicator of DME severity.
- Subjects
AQUEOUS humor; VITAMIN D; MULTIPLE regression analysis; EDEMA; SERUM
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2019, Vol 257, Issue 6, p1191
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-019-04305-2