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- Title
Cholecystokinin-2 receptor targeting by [<sup>68</sup>Ga]Ga-DOTA-MGS5 PET/CT in a patient with extensive disease small cell lung cancer.
- Authors
Di Santo, Gianpaolo; Santo, Giulia; Martinovic, Vladan; Wolf, Dominik; Pircher, Andreas; Sviridenko, Anna; Löffler-Ragg, Judith; von Guggenberg, Elisabeth; Virgolini, Irene
- Abstract
This article discusses the use of a radiolabeled peptide called DOTA-DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1-Nal-NH2, which targets the cholecystokinin-2 receptor (CCK2R), in a patient with extensive disease small cell lung cancer (ED-SCLC). The patient underwent PET/CT scans using [18F]FDG and [68Ga]Ga-DOTA-TOC, as well as [68Ga]Ga-DOTA-MGS5, to evaluate potential therapeutic options. The [68Ga]Ga-DOTA-MGS5 scan revealed high tracer uptake in all FDG-avid lesions and identified additional abnormal foci, suggesting disease progression. The study suggests that CCK2R-targeting may be a new theranostic tool for ED-SCLC patients.
- Subjects
SMALL cell lung cancer; LUNGS; DOPAMINE receptors
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2024, Vol 51, Issue 9, p2848
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-024-06749-z