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- Title
Differential Effects of Beta-Adrenergic Blockade on P<sub>0.1</sub> and Mean Inspiratory Flow.
- Authors
Chowanetz, W.; Balk, R.; Jany, B.
- Abstract
To quantitatively examine and compare the effects of β-adrenergic blockade on ventilation, we studied 20 healthy volunteers during inhalation of room air and at steady state CO2 (2.0, 4.4, 6.0%) following a single oral dose of bupranolol (vs. placebo). During room air breathing, minute ventilation (VE) and mean inspiratory flow (Vτ/Tι) were significantly reduced after β-blockade with a concomitant increase in blood PaCO2 (p < 0.01). The timing factor Tι/Ttot and mouth occlusion pressure P0.1 remained unchanged. These differences were, as shown from calculated effective alveolar ventilation, mainly attributed to a decrease in physiological dead space ventilation following β-blockade. With a stepwise increase in FICO2, the difference in PaCO2 between placebo and bupranolol tended to approach zero, whereas VE and Vτ/Tι remained significantly lower during β-blockade (P < 0.05). In contrast, no difference existed in P0.1 between bupranolol and placebo. We suggest that (1) respiratory drive assessed by P0.1 is unaffected by β-blockade and (2) mean inspiratory flow depends also on CO2 elimination characteristics, which are influenced by β-blockade Copyright © 1988 S. Karger AG, Basel
- Publication
Respiration, 1988, Vol 54, Issue 2, p94
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000195507