We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fluorinated quinolones possessing antituberculous activity.
- Authors
Lipunova, G. N.; Nosova, É. V.; Kravchenko, M. A.; Mochul'skaya, N. N.; Sidorova, L. P.; Tsoi, E. V.; Mokrushina, G. A.; Chasovskikh, O. M.; Charushin, V. N.
- Abstract
This article presents information on the rapid development of drug resistance in microbes, the toxicity and side effects of the existing antituberculous agents, and the lack of bactericidal preparations effective against stable mycobacteria. All these factors stimulate the effort directed toward the search for and development of new drugs. An important group of modern antibacterial drugs, so-called fluoroquinolones, is represented by synthetic derivatives of 4-oxo-6-fluoro-1,4-dihydroquinoline-3- carboxylic acid [2 - 4]. Thorough investigation into the properties of fluoroquinolones, especially those with polycyclic structures, revealed some new features of their biological activity spectrum such as antitumor and antiviral properties, including activity with respect to hepatitis C and HIV infection [5 - 7].
- Subjects
TUBERCULOSIS; DRUG side effects; IATROGENIC diseases; HIV infections; ACTINOMYCETALES; CARBOXYLIC acids; PHARMACOLOGY
- Publication
Pharmaceutical Chemistry Journal, 2004, Vol 38, Issue 11, p597
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-005-0037-8