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- Title
Specificity of peptide presentation by a set of hybrid mouse class I MHC molecules.
- Authors
Maryanski, Janet L.; Abastado, Jean-Pierre; Kourilsky, Philippe
- Abstract
The class I molecules of the major histocompatibility complex (H-2 in mouse, HLA in man) are membrane proteins composed of a polymorphic heavy chain associated with β-2-mieroglobulin. Recent studies suggest that class I molecules present peptides derived from processed antigens to the receptor of cytolytic T cells1,2. In particular, in the H-2d haplotype, synthetic HLA peptides can be recognized on K d-bearing target cells by Kd-restricted cytolytic T cells specific for HLA (ref.2). Here we analyse the specificity of presentation of two HLA peptides by a set of chimaeric K d/D d molecules3 to four different cytolytic T-cell clones. We identify two distinct regions within the second external (αa2) domain of K d that contribute to its specificity as a restriction element. Our results indicate that the binding of an immunogenic peptide by a class I molecule is not always sufficient for its recognition by the T-cell antigen receptor. This suggests that the major histocompatibility complex restriction element either interacts with the T-cell antigen receptor or induces the recognized conformation of the peptide.
- Publication
Nature, 1987, Vol 330, Issue 6149, p660
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/330660a0