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- Title
sAOP: linking chemical stressors to adverse outcomes pathway networks.
- Authors
Aguayo-Orozco, Alejandro; Audouze, Karine; Siggaard, Troels; Barouki, Robert; Brunak, Søren; Taboureau, Olivier
- Abstract
Motivation Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making. Results With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the 'cytotoxitiy burst' (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP components can be identified suggesting multiple effects not observed in the simplified 'one-biological perturbation to one-adverse outcome' model. The results may assist in the prioritization of chemicals to assess risk-based evaluations in the context of human health. Availability and implementation sAOP is available at http://saop.cpr.ku.dk Supplementary information Supplementary data are available at Bioinformatics online.
- Subjects
WIKIPEDIA; INTERNET servers; BIOACTIVE compounds; DEFINITIONS
- Publication
Bioinformatics, 2019, Vol 35, Issue 24, p5391
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btz570