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- Title
Dosage compensation in drosophila: Sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome.
- Authors
Gorchakov, Andrey A.; Alekseyenko, Artyom A.; Kharchenko, Peter V.; Park, Peter J.; Kuroda, Mitzi I.
- Abstract
For the dosage compensation to occur, genes on the single male X chromosomes in Drosophila must be selectively bound and acetylated by the ribonucleoprotein complex called MSL complex. It remained unknown how such exquisite specificity is achieved, and whether specific DNA sequences were involved. In the present work we demonstrate that it is transcription of the gene on the X chromosome that is important for MSL targeting, irrespective of gene origin and DNA sequence.
- Subjects
DROSOPHILA; NUCLEOTIDE sequence; SEX chromosomes; NUCLEOPROTEINS; GENETICS
- Publication
Russian Journal of Genetics, 2010, Vol 46, Issue 10, p1263
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795410100303