We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Thermoresponsive Zinc TetraPhenylPorphyrin Photosensitizer/Dextran Graft Poly(N-IsoPropylAcrylAmide) Copolymer/Au Nanoparticles Hybrid Nanosystem: Potential for Photodynamic Therapy Applications.
- Authors
Yeshchenko, Oleg A.; Kutsevol, Nataliya V.; Tomchuk, Anastasiya V.; Khort, Pavlo S.; Virych, Pavlo A.; Chumachenko, Vasyl A.; Kuziv, Yulia I.; Marinin, Andrey I.; Cheng, Lili; Nie, Guochao
- Abstract
The thermoresponsive Zinc TetraPhenylPorphyrin photosensitizer/Dextran poly (N-isopropylacrylamide) graft copolymer/Au Nanoparticles (ZnTPP/D-g-PNIPAM/AuNPs) triple hybrid nanosystem was synthesized in aqueous solution as a nanodrug for potential use in thermally driven and controlled photodynamic therapy applications. The aqueous solution of the nanosystem has demonstrated excellent stability in terms of aggregation and sedimentation several days after preparation. Optimal concentrations of the components of hybrid nanosystem providing the lowest level of aggregation and the highest plasmonic enhancement of electronic processes in the photosensitizer molecules have been determined. It has been revealed that the shrinking of D-g-PNIPAM macromolecule during a thermally induced phase transition leads to the release of both ZnTPP molecules and Au NPs from the ZnTPP/D-g-PNIPAM/AuNPs macromolecule and the strengthening of plasmonic enhancement of the electronic processes in ZnTPP molecules bound with the polymer macromolecule. The 2.7-fold enhancement of singlet oxygen photogeneration under resonant with surface plasmon resonance has been observed for ZnTPP/D-g-PNIPAM/AuNPs proving the plasmon nature of such effect. The data obtained in vitro on wild strains of Staphylococcus aureus have proved the high potential of such nanosystem for rapid photodynamic inactivation of microorganisms particular in wounds or ulcers on the body surface.
- Subjects
PHOTODYNAMIC therapy; GOLD nanoparticles; PHOTOSENSITIZERS; GRAFT copolymers; THERMORESPONSIVE polymers; TETRAPHENYLPORPHYRIN; DEXTRAN
- Publication
Nanomaterials (2079-4991), 2022, Vol 12, Issue 15, p2655
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano12152655