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- Title
INFLUENCE OF FLUVOXAMINE ON CARVEDILOL'S PHARMACOKINETICS IN RATS.
- Authors
ABRUDAN, MARIA BIANCA; MUNTEAN, DANA MARIA; VLASE, LAURIAN; GHELDIU, ANA-MARIA; BERCE, CRISTIAN; STOICESCU, LAURENȚIU; NEAG, MARIA ADRIANA
- Abstract
Carvedilol is one of the most used cardiovascular drugs, highly metabolized by CYP450 2D6, 1A2, 2C9. Fluvoxamine, an antidepressant agent, is a moderate/potent inhibitor of these enzymes. There is the risk of drug-drug interaction when these two drugs are concomitantly administered. The aim of this study was to investigate the drug-drug interactions between carvedilol and fluvoxamine in rats. There were two periods: reference and test. In the first period each rat received an oral dose of 3.57 mg/kg body weight carvedilol. In the test period, carvedilol was administered after a pre-treatment with multiple oral doses of fluvoxamine (14.28 mg/kg b.w.). HPLC-MS was used to determine the plasma concentration of carvedilol. The PK parameters were calculated by non-compartmental analysis. Fluvoxamine co-administered with carvedilol can change the PK parameters (increase AUC, t1/2, decrease the Cl). The present study demonstrated the pharmacokinetic drug-drug interaction between carvedilol and fluvoxamine in vivo.
- Subjects
CARVEDILOL; CARDIOVASCULAR agents; PHARMACOKINETICS; ANTIDEPRESSANTS; RATS
- Publication
Farmacia, 2019, Vol 67, Issue 4, p616
- ISSN
0014-8237
- Publication type
Article
- DOI
10.31925/farmacia.2019.4.9