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- Title
P-446: The calcium channel blocker nifedipine slows down the progression of coronary calcification in hypertensive patients as compared to diuretics.
- Authors
Motro, Michael; Shemesh, Joseph
- Abstract
Calcium controls numerous events within the vessel wall. Permeability of the endothelium is calcium dependent, as are platelet activation and adhesion, vascular smooth muscle proliferation and migration, and synthesis of fibrous connective tissue in the subendothelial space. Current evidence indicates that calcium channel blockers retard development of atherosclerosis in monkeys and rabbits. Human trials have evaluated sequential coronary angiograms in patients with symptomatic coronary artery disease.Double helix computerized tomography (DHCT) is a non-invasive technique which can detect, measure and compare coronary calcification in the coronary arteries. Using DHCT, our objective was to determine whether administration of nifedipine once daily in lieu of diuretics in high risk hypertensive patients will arrest or slow down the progression of coronary artery calcification. The study was designed as a side arm of the INSIGHT study, aimed to show the efficacy of nifedipine versus diuretics in high risk hypertensive patients.A total of 201 patients with total calcium score (TCS) of ≥ 10 at the onset of study who underwent an annual DHCT over three years were analyzed for efficacy.Inhibition of coronary calcium progression was significant in the nifedipine vs. the co-amilozide group during the first year [3.18% vs. 27% respectively (p=0.02)] non significant during the second year [28.5% vs. 47% respectively (p= 0.14)] and significant during the third year [40% vs. 78% respectively (p=0.02)].The results point to a slower progression of coronary calcification in patients on nifedipine once daily vs. co-amilozide.Am J Hypertens (2001) 14, 181A-181A; doi:S0895-7061(01)01618-1
- Publication
American Journal of Hypertension, 2001, Vol 14, p181A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(01)01618-1