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- Title
D005: Genetic predisposition of orthostatic dysregulation of blood pressure in the elderly in sekizen, japan.
- Authors
Tabara, Y.; Kohara*, K.; Yamamoto, Y.; Ueki, S.; Yano, H.; Ohnishi, M.; Igase, M.; Uemura, K.; Nakura, J.; Miki, T.
- Abstract
Orthostatic dysregulation of blood pressure has been shown to be associated with increase incidence of future cardiovascular event. The genetic background of orthostatic change of blood pressure was investigated in the community dwelling healthy elderly age ≥50 in Sekizen, Japan. One hundred ninety six subjects free from the medication were enrolled in the study. After 10 minutes rest in the supine position, brachial blood pressure was measured twice to obtain the basal blood pressure. Then blood pressure was measured at 1 and 3 minutes after standing up.Angiotensin converting enzyme (ACE) I/D, Angiotensinogen (AGT) M235T, angiotensin type 1 receptor (AT1R) A1166C, and APO E genotypes were determined for each patient. There was a significant difference in change in systolic blood pressure among APO E genotypes APOE24 + E34, APOE32, and APOE33, +5.1 ± 15.6, −4.4 ± 17.8, +5.4 ± 15.6 mmHg, respectively (p = 0.02). However, there were no significant difference in change in systolic blood pressure among genotypes of the renin-angiotensin system. Those findings indicates that genetic background is involved in orthostatic change in systolic blood pressure.Am J Hypertens (2000) 13, 74A-74A; doi:S0895-7061(00)00843-8
- Publication
American Journal of Hypertension, 2000, Vol 13, p74A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(00)00843-8