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- Title
Performance of the COMPASS-31 questionnaire with regard to autonomic nervous system testing results and medication use: a prospective study in a real-life setting.
- Authors
Ruška, Berislav; Pavičić, Tin; Pavlović, Ivan; Junaković, Anamari; Adamec, Ivan; Crnošija, Luka; Krbot Skorić, Magdalena; Habek, Mario
- Abstract
The aim of this study was to investigate the performance of the Composite Autonomic System Score-31 (COMPASS-31) questionnaire in a real-life setting in consecutive patients referred to the laboratory for objective testing of the autonomic nervous system (ANS), with the hypothesis that COMPASS-31 results differ depending on medications and findings of the tilt table test results. One hundred seventy-one consecutive patients (125 females, mean age 41.5 ± 19.3) referred for testing of the ANS were enrolled. Before testing, all patients completed the recently validated Croatian version of COMPASS-31. The following data were systematically collected for all patients: age, sex, diagnoses, and medications. Results of COMPASS-31 were significantly higher in patients taking medications with a known influence on the ANS (p < 0.001). Patients with postural orthostatic tachycardia had significantly higher orthostatic intolerance and vasomotor domains of COMPASS-31 (p = 0.048 and p = 0.022, respectively). Patients with a cardiovagal score ≥ 1 had a significantly higher vasomotor domain of COMPASS-31 compared to patients with normal results of ANS tests (p = 0.030). These findings suggest the COMPASS-31 might be a valuable screening tool for autonomic dysfunctions, as it is associated with impaired ANS tests, but usage of medications that modify the ANS should always be taken into account.
- Subjects
ORTHOSTATIC intolerance; DYSAUTONOMIA; AUTONOMIC nervous system; LONGITUDINAL method; DRUG utilization; AUTONOMIC nervous system diseases; NONPARAMETRIC statistics; SEVERITY of illness index; DIAGNOSIS
- Publication
Neurological Sciences, 2018, Vol 39, Issue 12, p2079
- ISSN
1590-1874
- Publication type
journal article
- DOI
10.1007/s10072-018-3542-8