We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Phaseolus vulgaris leukoagglutinating lectin-binding reactivity in human diffuse large B-cell lymphoma and its relevance to the patient’s clinical outcome: Lectin histochemistry and lectin blot analysis.
- Authors
Suzuki, Osamu; Nozawa, Yoshihiro; Kawaguchi, Takanori; Abe, Masafumi
- Abstract
Many reports have suggested a strong correlation between certain lectin-binding patterns and biological behavior in various tumors. To clarify a relationship between lectin-binding reactivity and survival of patients with diffuse large B-cell lymphoma (B-DLCL), 57 cases with B-DLCL were analyzed by lectin histochemistry and lectin blot method with or without treatment of neuraminidase or acidic hydrolytic conditions. B-DLCL cases were grouped into three types based on the data on lectin-binding reactivity under neuraminidase-treated or untreated conditions: (i) Group A (non-reactive type); (ii) Group B (sialylated type); and (iii) Group C (non-sialylated type). Among various lectins, Phaseolus vulgaris-L (L-PHA) binding reactivity showed that the survival of patients with Group A + B or Group B was significantly shorter than that of patients with Group C. Lectin blot analysis revealed failure of L-PHA-binding to 32 kd and 29 kd glycoproteins, which may be attributable to the masking of L-PHA-binding sites by sialylation or the lack of L-PHA-binding sites, leading to the short survival of patients with B-DLCL. L-PHA-binding reactivity may be a useful marker for the evaluation of survival of patients with B-DLCL.
- Subjects
B cell lymphoma; LECTINS; THERAPEUTICS; TUMOR treatment
- Publication
Pathology International, 1999, Vol 49, Issue 10, p874
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1046/j.1440-1827.1999.00960.x