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- Title
Rapid uptake of sumatriptan into the brain: An ongoing question of blood-brain barrier permeability.
- Authors
Holland, Philip R; Sureda-Gibert, Paula; Vila-Pueyo, Marta
- Abstract
This raises the possibility that sumatriptan may elicit CNS effects during migraine, demonstrating receptor occupancies comparable with opioids ([15]), with their known CNS actions. In this issue of I Cephalalgia i , Muzzi and colleagues ([16]) highlight an ultra-rapid CNS uptake of sumatriptan following subcutaneous administration in rats. A similar state-dependent alteration of the BBB has been proposed as far back as the 1970s with respect to migraine, with a "leaky" BBB proposed to increase CNS access during attacks ([23]); however, direct evidence for this is lacking. While the current study does not demonstrate the mechanisms responsible for sumatriptan CNS uptake in rats, it represents an interesting addition to the ongoing debate regarding CNS sites of action and headache.
- Subjects
BLOOD-brain barrier; PERMEABILITY; MIGRAINE aura; CALCITONIN gene-related peptide; LEPTIN; MITOGEN-activated protein kinases; CENTRAL nervous system; ANIMALS; BRAIN; CLUSTER headache; RATS; SUMATRIPTAN
- Publication
Cephalalgia, 2020, Vol 40, Issue 4, p327
- ISSN
0333-1024
- Publication type
editorial
- DOI
10.1177/0333102420905131