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- Title
Altered neurochemical coupling in the occipital cortex in migraine with visual aura.
- Authors
Bridge, Holly; Stagg, Charlotte J.; Near, Jamie; Lau, Chi-ieong; Zisner, Aimee; Cader, M. Zameel
- Abstract
<bold>Background: </bold>Visual aura is present in about one-third of migraine patients and triggering by bright or flickering lights is frequently reported.<bold>Method: </bold>Using migraine with visual aura patients, we investigated the neurochemical profile of the visual cortex using magnetic resonance spectroscopy. Specifically, glutamate/creatine and GABA/creatine ratios were quantified in the occipital cortex of female migraine patients.<bold>Results: </bold>GABA levels in the occipital cortex of migraine patients were lower than that of controls. Glutamate levels in migraine patients, but not controls, correlated with the blood-oxygenation-level-dependent (BOLD) signal in the primary visual cortex during visual stimulation.<bold>Conclusion: </bold>Migraine with visual aura appears to disrupt the excitation-inhibition coupling in the occipital cortex.
- Subjects
MIGRAINE; OCCIPITAL lobe; NEUROCHEMISTRY; VISUAL acuity; MAGNETIC resonance imaging of the brain; GLUTAMIC acid metabolism; BIOCHEMISTRY; GABA; GLUTAMIC acid; PHENOMENOLOGY; NUCLEAR magnetic resonance spectroscopy; RESEARCH funding
- Publication
Cephalalgia, 2015, Vol 35, Issue 11, p1025
- ISSN
0333-1024
- Publication type
journal article
- DOI
10.1177/0333102414566860