We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype.
- Authors
Tsou, Meng-Ting; Yun, Chun-Ho; Lin, Jiun-Lu; Sung, Kuo-Tzu; Tsai, Jui-Peng; Huang, Wen-Hung; Liu, Chia-Yuan; Hou, Charles Jia-Yin; Tsai, I.-Hsien; Su, Cheng-Huang; Hung, Chung-Lieh; Hung, Ta-Chuan
- Abstract
The debate regarding the actual cardiovascular burden in metabolically healthy obese or metabolically unhealthy non-obesity individuals is ongoing. Accumulating data have suggested a unique pathophysiological role of pro-inflammatory cytokines in mediating metabolic and cardiovascular disorders by dysregulated visceral adiposity. To compare the burden of visceral adiposity, the inflammatory marker high-sensitivity C-reactive protein (hs-CRP) and the prevalent atherosclerotic burden in metabolically healthy obese (MHO) or metabolically unhealthy (MU) populations, were compared to those of metabolically healthy non-obesity subjects (MHNO). Coronary artery calcification score (CACS) and visceral fat, including pericardial fat (PCF)/thoracic peri-aortic fat (TAT), were quantified in 2846 asymptomatic subjects using a CT dataset. A cross-sectional analysis comparing CACS, inflammatory marker hs-CRP, and visceral fat burden among four obesity phenotypes (MHNO, metabolically unhealthy non-obesity (MUNO), MHO, and metabolically unhealthy obese (MUO)) was performed. Both MUNO and MUO demonstrated significantly higher hs-CRP and greater CACS than MHNO/MHO (adjusted coefficient: 25.46, 95% confidence interval (CI): 5.29–45.63; 43.55, 95% CI: 23.38–63.73 for MUNO and MUO (MHNO as reference); both p < 0.05). Visceral fat (PCF/TAT) was an independent determinant of MU and was similarly higher in the MUNO/MHO groups than in the MHNO group, with the MUO group having the largest amount. PCF/TAT, obesity, and MU remained significantly associated with higher CACS even after adjustment, with larger PCF/TAT modified effects for MU and diabetes in CACS (both pinteraction < 0.05). MU tightly linked to excessive visceral adiposity was a strong and independent risk factor for coronary atherosclerosis even in lean individuals, which could be partially explained by its coalignment with pathological pro-inflammatory signaling.
- Subjects
OBESITY; PHENOTYPES; CARDIOVASCULAR diseases; CALCIFICATION; C-reactive protein; VISCERAL pain; METABOLIC disorders
- Publication
Diagnostics (2075-4418), 2021, Vol 11, Issue 1, p40
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics11010040