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- Title
IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas.
- Authors
Falini, Brunangelo; Agostinelli, Claudio; Bigerna, Barbara; Pucciarini, Alessandra; Pacini, Roberta; Tabarrini, Alessia; Falcinelli, Flavio; Piccioli, Milena; Paulli, Marco; Gambacorta, Marcello; Ponzoni, Maurilio; Tiacci, Enrico; Ascani, Stefano; Martelli, Maria Paola; Favera, Riccardo Dalla; Stein, Harald; Pileri, Stefano A
- Abstract
Falini B, Agostinelli C, Bigerna B, Pucciarini A, Pacini R, Tabarrini A, Falcinelli F, Piccioli M, Paulli M, Gambacorta M, Ponzoni M, Tiacci E, Ascani S, Martelli M P, Dalla Favera R, Stein H & Pileri S A (2012) Histopathology 61, 930-941 IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas Aims: The aim of this study was to search for a molecule selectively expressed by marginal zone (MZ) lymphomas (MZLs), whose diagnosis is currently based on morphological criteria and negativity for markers detectable in other B-cell lymphomas. Methods and results: Two thousand one hundred and four peripheral lymphomas of various types were immunostained with a monoclonal antibody against immunoglobulin superfamily receptor translocation-associated 1 (IRTA1), which recognizes the equivalents of MZ in human lymphoid tissues other than spleen. IRTA1 expression was restricted to extranodal (93%) and nodal MZLs (73%) and to lymphomas with MZ differentiation. Extranodal MZL cells with the strongest IRTA1 expression were usually located adjacent to epithelia, mimicking the IRTA1 expression pattern of normal and acquired mucosa-associated lymphoid tissue (MALT). The cytological features, growth pattern and IRTA1 positivity in nodal MZLs suggest they may derive from IRTA1+ perifollicular B cells or monocytoid B cells detectable in reactive lymph nodes. Double immunostaining for IRTA1/bcl-6 tracked the colonization of B-cell follicles by MZL cells, and showed modulation of their phenotype (e.g. acquisition of bcl-6) during recirculation through germinal centres. MZL cells differentiating into plasma cells usually lost IRTA1. Conclusions: These results further expand our knowledge of the biology of MZLs, and highlight IRTA1 as the first positive marker for MZLs, enabling more accurate diagnosis of these neoplasms.
- Subjects
LYMPHOMA diagnosis; B cell receptors; CELL differentiation; CYTOLOGY; CHROMOSOMAL translocation; B cells
- Publication
Histopathology, 2012, Vol 61, Issue 5, p930
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2012.04289.x